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Des-(Pyrazino[2,1-b][1,3]oxazin-2-yl) 4-(3-hydroxy)piperazin-1-yl Venetoclax-M27

Des-(Pyrazino[2,1-b][1,3]oxazin-2-yl) 4-(3-hydroxy)piperazin-1-yl Venetoclax-M27

Catalog:	BB068728
Product Name:	Des-(Pyrazino[2,1-b][1,3]oxazin-2-yl) 4-(3-hydroxy)piperazin-1-yl Venetoclax-M27
Synonyms:	2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-3-hydroxy-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide

Technical Data

Description:	Des-(Pyrazino[2,1-b][1,3]oxazin-2-yl) 4-(3-hydroxy)piperazin-1-yl Venetoclax-M27 is an intermediate in the synthesis of Venetoclax-M27 (V121010), a derivative of Venetoclax (ABT 199), which is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It's practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
Molecular Weight:	884.45
Molecular Formula:	C45H50ClN7O8S
References:	Davids, M. & Letai, A. Cancer Cell, 23, 139 (2013); Souers, A., et al. Nat. Med., 19, 202 (2013); Vaillant, F., et al. Cancer Cell, 24, 120 (2013); Vogler, M., et al. Brit. J. Haematol., 163, 139 (2013).

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