Dehydroxy Tetrabenzyloxy Canagliflozin

Catalog: BB068614
Product Name: Dehydroxy Tetrabenzyloxy Canagliflozin
Synonyms: (2S,3R,4S,5R,6R)-3,4,5-Tris(benzyloxy)-6-((benzyloxy)methyl)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-2-ol
Description:Dehydroxy Benzyloxy Canagliflozin is an intermediate in the synthesis of Canagliflozin Dimer (C175225), a dimer impurity of Canagliflozin (C175190); a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
Molecular Weight:821.02
Molecular Formula:C52H49FO6S
Solubility:Chloroform; Dichloromethane; Ethyl Acetate
References:Chao, E. et al. Drug Fut., 36, 351 (2011); Sha, S. et al. Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S. Clin. Invest., 1, 145 (2011).

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