Dehydroxy Bezyloxy Canagliflozin Dimer
Catalog: |
BB068610 |
Product Name: |
Dehydroxy Bezyloxy Canagliflozin Dimer |
Synonyms: |
(2S,3R,4S,5R,6R)-3,4,5-Tris(benzyloxy)-6-((benzyloxy)methyl)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2-(((2R,3R,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-2-yl)methoxy)tetrahydro-2H-pyran |
Description: | Dehydroxy Bezyloxy Canagliflozin Dimer is an intermediate in the synthesis of Canagliflozin Dimer (C175225), a dimer impurity of Canagliflozin (C175190); a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. |
Molecular Weight: | 1517.89 |
Molecular Formula: | C97H90F2O10S2 |
Solubility: | Chloroform; Dichloromethane; Ethyl Acetate |
Appearance: | White solid |
References: | Chao, E. et al. Drug Fut., 36, 351 (2011); Sha, S. et al. Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S. Clin. Invest., 1, 145 (2011). |
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