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Medicinal chemistry and drug research require diverse chemical components to meet strict requirements not only in terms of physical and chemical properties but also in terms of chemical reactivity.
Medicinal chemistry and drug research require diverse chemical components to meet strict requirements not only in terms of physical and chemical properties but also in terms of chemical reactivity.
The chemists use the 'build–couple–pair' strategy of organic synthesis, which entails preparing molecular building blocks that contain several chemical groups.
The chemical building block (CBB) is a molecule which can be converted to various secondary chemicals and intermediates, and, in turn, into a broad range of different downstream uses.
| Description: | Cystamine dihydrochloride is the dihydrochloride salt of cystamine, which is an organic disulfide that inhibits tissue transglutaminase (TGM2) with an IC50 value of approximately 2.5 mM. It is orally available, and decreases aggregated and cross-linked huntingtin in transfected cells. It is neuroprotective in mouse models of Huntington's disease. It has exhibited suppressive effects against HIV replication in infected human cells. It could extend survival and improve motor performance in transgenic HD mice. It inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease. |
| Molecular Weight: | 225.20 |
| Molecular Formula: | C4H14Cl2N2S2 |
| Canonical SMILES: | C(CSSCCN)N.Cl.Cl |
| InChI: | InChI=1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6;;/h1-6H2;2*1H |
| InChI Key: | YUFRRMZSSPQMOS-UHFFFAOYSA-N |
| Boiling Point: | 264.8 ℃ at 760 mmHg |
| Melting Point: | 217-220 ℃ |
| Flash Point: | 113 ℃ |
| Purity: | > 97 % |
| Density: | 1.172 g/cm3 |
| Storage: | Inert atmosphere. Room temperature. |
| MDL: | MFCD00012905 |
| LogP: | 3.28980 |
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