BS3 Crosslinker - CAS 82436-77-9

Name: BS3 Crosslinker
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB036820
Product Name:	BS3 Crosslinker
CAS:	82436-77-9
Synonyms:	Bis(sulfosuccinimidyl)suberate

Technical Data

IUPAC Name:	1-[8-(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy-8-oxooctanoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid
Description:	BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Molecular Weight:	528.47
Molecular Formula:	C16H20N2O14S2
Canonical SMILES:	C1C(C(=O)N(C1=O)OC(=O)CCCCCCC(=O)ON2C(=O)CC(C2=O)S(=O)(=O)O)S(=O)(=O)O
InChI:	InChI=1S/C16H20N2O14S2/c19-11-7-9(33(25,26)27)15(23)17(11)31-13(21)5-3-1-2-4-6-14(22)32-18-12(20)8-10(16(18)24)34(28,29)30/h9-10H,1-8H2,(H,25,26,27)(H,28,29,30)
InChI Key:	VYLDEYYOISNGST-UHFFFAOYSA-N
Melting Point:	>300°C
Purity:	≥ 97.0 %
Solubility:	10 mm in DMSO
Appearance:	Light tan powder
Storage:	Store at -5 °C, keep in dry and avoid sunlight.
LogP:	-0.03120

GHS Hazard Statement:	H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement:	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word:	Warning

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PMID	Publication Date	Title	Journal
25971889	20150514	Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion	Molecular cancer
23109106	20121201	Selective cell recruitment and spatially controlled cell attachment on instructive chitosan surfaces functionalized with antibodies	Biointerphases
22783892	20120813	Synthesis and cell adhesive properties of linear and cyclic RGD functionalized polynorbornene thin films	Biomacromolecules
22619173	20120727	Hydrophobic matching controls the tilt and stability of the dimeric platelet-derived growth factor receptor (PDGFR) β transmembrane segment	The Journal of biological chemistry
22470150	20120401	A protein cross-linking assay for measuring cell surface expression of glutamate receptor subunits in the rodent brain after in vivo treatments	Current protocols in neuroscience

Complexity:	1010
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	528.03559566
Formal Charge:	0
Heavy Atom Count:	34
Hydrogen Bond Acceptor Count:	14
Hydrogen Bond Donor Count:	2
Isotope Atom Count:	0
Monoisotopic Mass:	528.03559566
Rotatable Bond Count:	13
Topological Polar Surface Area:	253 Å²
Undefined Atom Stereocenter Count:	2
Undefined Bond Stereocenter Count:	0
XLogP3:	-1