Bis-PEG7-acid - CAS 94376-75-7
Catalog: |
BB041284 |
Product Name: |
Bis-PEG7-acid |
CAS: |
94376-75-7 |
Synonyms: |
4,7,10,13,16,19,22-Heptaoxapentacosanedioic acid; HOOCCH2CH2O-PEG6-CH2CH2COOH; α,ω-Dipropionic acid hexaethylene glycol; 4,7,10,13,16,19,22-Heptaoxapentacosane-1,25-dioic acid |
Related CAS: | 51178-68-8 (polymer)
|
IUPAC Name: | 3-[2-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
Description: | Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
Molecular Weight: | 426.46 |
Molecular Formula: | C18H34O11 |
Canonical SMILES: | C(COCCOCCOCCOCCOCCOCCOCCC(=O)O)C(=O)O |
InChI: | InChI=1S/C18H34O11/c19-17(20)1-3-23-5-7-25-9-11-27-13-15-29-16-14-28-12-10-26-8-6-24-4-2-18(21)22/h1-16H2,(H,19,20)(H,21,22) |
InChI Key: | AYUREXAVZVVOJM-UHFFFAOYSA-N |
Boiling Point: | 572.8±50.0 °C at 760 mmHg |
Purity: | ≥95% |
Density: | 1.186±0.06 g/cm3 |
Solubility: | Soluble in DMSO |
Appearance: | Pale Yellow or Colorless Oily Matter |
Storage: | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
LogP: | 0.05200 |
Publication Number | Title | Priority Date |
WO-2020132618-A1 | Photocleavable linker for catching and/or releasing of circulating tumor cells or extracellular vesicles | 20181221 |
WO-2019212356-A1 | Tetrazines for high click conjugation yield in vivo and high click release yield | 20180504 |
WO-2019212357-A1 | Compounds comprising a linker for increasing transcyclooctene stability | 20180504 |
AU-2019262520-A1 | Tetrazines for high click conjugation yield in vivo and high click release yield | 20180504 |
AU-2019262521-A1 | Compounds comprising a linker for increasing transcyclooctene stability | 20180504 |
Complexity: | 345 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 426.2101119 |
Formal Charge: | 0 |
Heavy Atom Count: | 29 |
Hydrogen Bond Acceptor Count: | 11 |
Hydrogen Bond Donor Count: | 2 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 426.2101119 |
Rotatable Bond Count: | 24 |
Topological Polar Surface Area: | 139 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | -1.8 |
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