Benzylhydrazine dihydrochloride - CAS 20570-96-1
Catalog: |
BB016070 |
Product Name: |
Benzylhydrazine dihydrochloride |
CAS: |
20570-96-1 |
Synonyms: |
benzylhydrazine;dihydrochloride |
IUPAC Name: | benzylhydrazine;dihydrochloride |
Description: | Benzylhydrazine dihydrochloride (CAS# 20570-96-1) is used in preparation of heterocyclyl amides as inhibitors of receptor interacting protein kinase 1 (RIPK1) for the treatment of disease. |
Molecular Weight: | 195.09 |
Molecular Formula: | C7H12Cl2N2 |
Canonical SMILES: | C1=CC=C(C=C1)CNN.Cl.Cl |
InChI: | InChI=1S/C7H10N2.2ClH/c8-9-6-7-4-2-1-3-5-7;;/h1-5,9H,6,8H2;2*1H |
InChI Key: | MSJHOJKVMMEMNX-UHFFFAOYSA-N |
Boiling Point: | 265.4 °C at 760 mmHg |
Density: | 1.033 g/cm3 |
MDL: | MFCD00012921 |
LogP: | 3.34510 |
GHS Hazard Statement: | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] |
Precautionary Statement: | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
EP-3901142-A1 | Pyrazolylbenzene-1,3-diols for diseases associated with g protein-coupled receptor 18 and in combination with transient receptor potential vanilloid 1 | 20200421 |
US-2021323927-A1 | Pyrazolylbenzene-1,3-diols for diseases associated with g protein-coupled receptor 18 and in combination with transient receptor potential vanilloid 1 | 20200417 |
CN-111072714-A | Method for preparing intermediate containing fluorosilane | 20191231 |
US-2021094951-A1 | Inhibitors of receptor interacting protein kinase i for the treatment of disease | 20190906 |
WO-2021046515-A1 | Inhibitors of receptor interacting protein kinase i for the treatment of disease | 20190906 |
PMID | Publication Date | Title | Journal |
18607080 | 20080701 | Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine | Acta crystallographica. Section F, Structural biology and crystallization communications |
15186849 | 20040701 | Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay | Bioorganic & medicinal chemistry |
43225 | 19791101 | The metabolic disposition of [14C]pivhydrazine, [14C]mebanazine, and [14C]benzylhydrazine in the rat | Drug metabolism and disposition: the biological fate of chemicals |
Complexity: | 67.3 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 3 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 194.0377538 |
Formal Charge: | 0 |
Heavy Atom Count: | 11 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 4 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 194.0377538 |
Rotatable Bond Count: | 2 |
Topological Polar Surface Area: | 38 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
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