Anavex 2-73 HCl - CAS 195615-84-0
Catalog: |
BB015138 |
Product Name: |
Anavex 2-73 HCl |
CAS: |
195615-84-0 |
Synonyms: |
Blarcamesine hydrochloride; AVex-73 hydrochloride; AE-37 hydrochloride |
IUPAC Name: | 1-(2,2-diphenyloxolan-3-yl)-N,N-dimethylmethanamine;hydrochloride |
Description: | Anavex 2-73 is a mixed muscarinic and sigma-1/σ1 Receptor agonist with neuroprotective effects. |
Molecular Weight: | 317.85 |
Molecular Formula: | C19H24ClNO |
Canonical SMILES: | CN(C)CC1CCOC1(C2=CC=CC=C2)C3=CC=CC=C3.Cl |
InChI: | InChI=1S/C19H23NO.ClH/c1-20(2)15-18-13-14-21-19(18,16-9-5-3-6-10-16)17-11-7-4-8-12-17;/h3-12,18H,13-15H2,1-2H3;1H |
InChI Key: | FEQOLYDPQKHFTD-UHFFFAOYSA-N |
LogP: | 4.33030 |
GHS Hazard Statement: | H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
Precautionary Statement: | P273, P391, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
WO-2021158586-A1 | Solid state forms of blarcamesine salts | 20200204 |
WO-2021016314-A1 | Anavex2-73 for the treatment of genetic neurodevelopmental disorders | 20190722 |
WO-2021016314-A9 | Anavex2-73 for the treatment of genetic neurodevelopmental disorders | 20190722 |
WO-2020118086-A1 | Compositions and methods for regulating inflammation | 20181205 |
EP-3880209-A1 | Compositions and methods for regulating inflammation | 20181205 |
PMID | Publication Date | Title | Journal |
31704481 | 20191201 | ANAVEX®2-73 (blarcamesine), a Sigma-1 receptor agonist, ameliorates neurologic impairments in a mouse model of Rett syndrome | Pharmacology, biochemistry, and behavior |
26386305 | 20160101 | Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments | Behavioural brain research |
25653589 | 20140101 | Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25-35 peptide-injected mice, a nontransgenic Alzheimer's disease model | Frontiers in cellular neuroscience |
23493042 | 20130801 | Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology |
20829307 | 20110801 | Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative | Journal of psychopharmacology (Oxford, England) |
Complexity: | 298 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 2 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 317.1546421 |
Formal Charge: | 0 |
Heavy Atom Count: | 22 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 317.1546421 |
Rotatable Bond Count: | 4 |
Topological Polar Surface Area: | 12.5 Å2 |
Undefined Atom Stereocenter Count: | 1 |
Undefined Bond Stereocenter Count: | 0 |
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