Anavex 2-73 HCl - CAS 195615-84-0

Catalog:	BB015138
Product Name:	Anavex 2-73 HCl
CAS:	195615-84-0
Synonyms:	Blarcamesine hydrochloride; AVex-73 hydrochloride; AE-37 hydrochloride

Technical Data

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Patents

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Computed Properties

IUPAC Name:	1-(2,2-diphenyloxolan-3-yl)-N,N-dimethylmethanamine;hydrochloride
Description:	Anavex 2-73 is a mixed muscarinic and sigma-1/σ1 Receptor agonist with neuroprotective effects.
Molecular Weight:	317.85
Molecular Formula:	C19H24ClNO
Canonical SMILES:	CN(C)CC1CCOC1(C2=CC=CC=C2)C3=CC=CC=C3.Cl
InChI:	InChI=1S/C19H23NO.ClH/c1-20(2)15-18-13-14-21-19(18,16-9-5-3-6-10-16)17-11-7-4-8-12-17;/h3-12,18H,13-15H2,1-2H3;1H
InChI Key:	FEQOLYDPQKHFTD-UHFFFAOYSA-N
LogP:	4.33030

Publication Number	Title	Priority Date
WO-2021158586-A1	Solid state forms of blarcamesine salts	20200204
WO-2021016314-A1	Anavex2-73 for the treatment of genetic neurodevelopmental disorders	20190722
WO-2021016314-A9	Anavex2-73 for the treatment of genetic neurodevelopmental disorders	20190722
WO-2020118086-A1	Compositions and methods for regulating inflammation	20181205
EP-3880209-A1	Compositions and methods for regulating inflammation	20181205

PMID	Publication Date	Title	Journal
31704481	20191201	ANAVEX®2-73 (blarcamesine), a Sigma-1 receptor agonist, ameliorates neurologic impairments in a mouse model of Rett syndrome	Pharmacology, biochemistry, and behavior
26386305	20160101	Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments	Behavioural brain research
25653589	20140101	Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25-35 peptide-injected mice, a nontransgenic Alzheimer's disease model	Frontiers in cellular neuroscience
23493042	20130801	Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
20829307	20110801	Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative	Journal of psychopharmacology (Oxford, England)

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GHS Hazard Statement:	H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
Precautionary Statement:	P273, P391, and P501
Signal Word:	Warning

Complexity:	298
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	2
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	317.1546421
Formal Charge:	0
Heavy Atom Count:	22
Hydrogen Bond Acceptor Count:	2
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	317.1546421
Rotatable Bond Count:	4
Topological Polar Surface Area:	12.5 Å²
Undefined Atom Stereocenter Count:	1
Undefined Bond Stereocenter Count:	0