Aminooxy-PEG1-alcohol - CAS 3279-95-6
Catalog: |
BB021418 |
Product Name: |
Aminooxy-PEG1-alcohol |
CAS: |
3279-95-6 |
Synonyms: |
2-(Aminooxy)ethan-1-ol; Ethanol, 2-(aminooxy)-; O-(2-Hydroxyethyl)hydroxylamine |
IUPAC Name: | 2-aminooxyethanol |
Description: | Aminooxy-PEG1-alcohol is a non-cleavable 1-unit PEG ADC linker that is used in the synthesis of antibody conjugated drugs (ADCs). Aminooxy-PEG1-alcohol is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules. |
Molecular Weight: | 77.08 |
Molecular Formula: | C2H7NO2 |
Canonical SMILES: | C(CON)O |
InChI: | InChI=1S/C2H7NO2/c3-5-2-1-4/h4H,1-3H2 |
InChI Key: | WWWTWPXKLJTKPM-UHFFFAOYSA-N |
Boiling Point: | 61-62°C at 1 Torr |
Purity: | ≥95% |
Density: | 1.115±0.06 g/cm3 at 20°C, 760 Torr |
Appearance: | Pale Yellow or Colorless Oily Matter |
Storage: | Store at 2-8°C under inert gas (nitrogen or Argon) |
LogP: | -0.43070 |
GHS Hazard Statement: | H227 (100%): Combustible liquid [Warning Flammable liquids] |
Precautionary Statement: | P210, P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
WO-2021198709-A1 | Naphthyridine compounds as inhibitors of mer tyrosine kinase and axl tyrosine kinase | 20200403 |
WO-2021149776-A1 | Arylamide derivative having antitumor activity | 20200122 |
WO-2021104441-A1 | Polyaromatic compound as egfr kinase inhibitor | 20191129 |
WO-2021060351-A1 | Nsaid-bonded alginic acid derivative | 20190925 |
WO-2021060395-A1 | Sustained-release pharmaceutical composition | 20190925 |
PMID | Publication Date | Title | Journal |
21448306 | 20110304 | Expression of human globular adiponectin-glucagon-like peptide-1 analog fusion protein and its assay of glucose-lowering effect in vivo | International journal of medical sciences |
22114475 | 20110101 | Cytotoxicity of naphthoquinones and their capacity to generate reactive oxygen species is quenched when conjugated with gold nanoparticles | International journal of nanomedicine |
21270961 | 20101208 | Pegylation of poly(γ-benzyl-L-glutamate) nanoparticles is efficient for avoiding mononuclear phagocyte system capture in rats | International journal of nanomedicine |
21578482 | 20091028 | (RSS)-[N-Hydroxyethyloxy]-hexafluoroVal-MeLeu-Ala tert-butyl ester | Acta crystallographica. Section E, Structure reports online |
17722551 | 20070101 | Lead sulfide near-infrared quantum dot bioconjugates for targeted molecular imaging | International journal of nanomedicine |
Complexity: | 17.1 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 77.047678466 |
Formal Charge: | 0 |
Heavy Atom Count: | 5 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 2 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 77.047678466 |
Rotatable Bond Count: | 2 |
Topological Polar Surface Area: | 55.5 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | -1.4 |
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