Aminoguanidine hydrochloride - CAS 1937-19-5

Name: Aminoguanidine hydrochloride
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB015012
Product Name:	Aminoguanidine hydrochloride
CAS:	1937-19-5
Synonyms:	Pimagedine hydrochloride

Technical Data

IUPAC Name:	2-aminoguanidine;hydrochloride
Description:	Aminoguanidine hydrochloride is the hydrochloride salt form of Aminoguanidine. Aminoguanidine is an inhibitor that has an irreversible function on iNOS with selectivity against eNOS and nNOS. IC50: iNOS= 5.4 µM; rat nNOS= 160 µM.
Molecular Weight:	110.55
Molecular Formula:	CH7ClN4
Canonical SMILES:	C(=NN)(N)N.Cl
InChI:	InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
InChI Key:	UBDZFAGVPPMTIT-UHFFFAOYSA-N
Boiling Point:	261.4 °C at 760 mmHg
Melting Point:	163-164 °C
Solubility:	Soluble to > 43 mg/mL in H2O
Appearance:	Crystalline solid
Storage:	Store in a cool, dry and dark place. Hygroscopic.
MDL:	MFCD00039074
LogP:	1.03640

GHS Hazard Statement:	H315 (97.37%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement:	P201, P202, P261, P264, P271, P272, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501
Signal Word:	Danger

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US-9365574-B2	Soluble guanylate cyclase activators	20100527
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PMID	Publication Date	Title	Journal
29935243	20180801	NF-κB-iNOS-COX2-TNF α inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
29499192	20180425	Evidence for the involvement of TNF-α, IL-1β and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents	Chemico-biological interactions
28242320	20170415	A positive feedback loop between nitric oxide and amyloid β (1-42) accelerates mitochondrial damage in human lens epithelial cells	Toxicology
28223158	20170301	Aminoguanidine alleviated MMA-induced impairment of cognitive ability in rats by downregulating oxidative stress and inflammatory reaction	Neurotoxicology
23921152	20131115	Arsenic toxicity induced endothelial dysfunction and dementia: pharmacological interdiction by histone deacetylase and inducible nitric oxide synthase inhibitors	Toxicology and applied pharmacology

Complexity:	41.6
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	2
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	110.0359239
Formal Charge:	0
Heavy Atom Count:	6
Hydrogen Bond Acceptor Count:	2
Hydrogen Bond Donor Count:	4
Isotope Atom Count:	0
Monoisotopic Mass:	110.0359239
Rotatable Bond Count:	0
Topological Polar Surface Area:	90.4 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0