Aminoguanidine hydrochloride - CAS 1937-19-5
Catalog: |
BB015012 |
Product Name: |
Aminoguanidine hydrochloride |
CAS: |
1937-19-5 |
Synonyms: |
2-aminoguanidine;hydrochloride |
IUPAC Name: | 2-aminoguanidine;hydrochloride |
Description: | Aminoguanidine hydrochloride is the hydrochloride salt form of Aminoguanidine. Aminoguanidine is an inhibitor that has an irreversible function on iNOS with selectivity against eNOS and nNOS. IC50: iNOS= 5.4 µM; rat nNOS= 160 µM. |
Molecular Weight: | 110.55 |
Molecular Formula: | CH7ClN4 |
Canonical SMILES: | C(=NN)(N)N.Cl |
InChI: | InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H |
InChI Key: | UBDZFAGVPPMTIT-UHFFFAOYSA-N |
Boiling Point: | 261.4 ℃ at 760 mmHg |
Melting Point: | 163-164 ℃ |
Solubility: | Soluble to > 43 mg/mL in H2O |
Appearance: | Crystalline solid |
Storage: | Store in a cool and dry place and at 0 - 4 ℃ for short term (days to weeks) or -76 ℃ for long term (months to years). |
MDL: | MFCD00039074 |
LogP: | 1.03640 |
GHS Hazard Statement: | H315 (97.37%): Causes skin irritation [Warning Skin corrosion/irritation] |
Precautionary Statement: | P201, P202, P261, P264, P271, P272, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
US-2014242135-A1 | Compositions for inhibition of insect sensing | 20110506 |
US-2013072492-A1 | Soluble guanylate cyclase activators | 20100527 |
US-9365574-B2 | Soluble guanylate cyclase activators | 20100527 |
US-2012283441-A1 | Method For Producing Pyrimidinylpyrazole Compounds | 20100118 |
US-8592582-B2 | Method for producing pyrimidinylpyrazole compounds | 20100118 |
PMID | Publication Date | Title | Journal |
29935243 | 20180801 | NF-κB-iNOS-COX2-TNF α inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association |
29499192 | 20180425 | Evidence for the involvement of TNF-α, IL-1β and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents | Chemico-biological interactions |
28242320 | 20170415 | A positive feedback loop between nitric oxide and amyloid β (1-42) accelerates mitochondrial damage in human lens epithelial cells | Toxicology |
28223158 | 20170301 | Aminoguanidine alleviated MMA-induced impairment of cognitive ability in rats by downregulating oxidative stress and inflammatory reaction | Neurotoxicology |
23921152 | 20131115 | Arsenic toxicity induced endothelial dysfunction and dementia: pharmacological interdiction by histone deacetylase and inducible nitric oxide synthase inhibitors | Toxicology and applied pharmacology |
Complexity: | 41.6 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 2 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 110.0359239 |
Formal Charge: | 0 |
Heavy Atom Count: | 6 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 4 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 110.0359239 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 90.4 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
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