IUPAC Name: | 9-[(2R,5R)-5-methyloxolan-2-yl]purin-6-amine |
Description: | 9-(Tetrahydro-5-methyl-2-furyl)adenine (Didanosine EP Impurity H) is an impurity of Didanosine (D440950), which used as an antiviral agent. Classed as an anti-retroviral drug used in the treatment of HIV in ART therapy, it also may increase acetaminophen related hepatotoxicity by enhancing mitochrondrial dysfunction (2). |
Molecular Weight: | 220.23 |
Molecular Formula: | C10H12N4O2 |
Canonical SMILES: | CC1CCC(O1)N2C=NC3=C(N=CN=C32)N |
InChI: | InChI=1S/C10H13N5O/c1-6-2-3-7(16-6)15-5-14-8-9(11)12-4-13-10(8)15/h4-7H,2-3H2,1H3,(H2,11,12,13)/t6-,7-/m1/s1 |
InChI Key: | PSPPXRNUZVTTON-RNFRBKRXSA-N |
References: | 1. Esplugues, J. et al. AIDS. 2016 Jun 1;30(9):1341-51.2. Blas-Garcia, A. et al. J. Antimicrob. Chemother. 2016 Apr;71(4):916-26. |
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