9-Phenanthrol - CAS 484-17-3
Catalog: |
BB026538 |
Product Name: |
9-Phenanthrol |
CAS: |
484-17-3 |
Synonyms: |
phenanthren-9-ol |
Application: |
Protein Kinase Inhibitors |
IUPAC Name: | phenanthren-9-ol |
Description: | 9-Phenanthrol, a cell permeable hydroxytricyclic derivative, functions as a selective inhibitor of TRPM4 (IC50 = 20 μM in HEK293 cells) and exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). 9-Phenanthrol was used to investigate C K-edge and O K-edge near-edge X-ray absorption fine structure (NEXAFS) spectra of single-wall carbon nanotubes. |
Molecular Weight: | 194.23 |
Molecular Formula: | C14H10O |
Canonical SMILES: | C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O |
InChI: | InChI=1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H |
InChI Key: | DZKIUEHLEXLYKM-UHFFFAOYSA-N |
Boiling Point: | 404.5 ℃ at 760 mmHg |
Density: | 1.244 g/cm3 |
Appearance: | Brown powder |
Storage: | Store in a cool and dry place (or refer to the Certificate of Analysis). |
MDL: | MFCD00082298 |
LogP: | 3.69860 |
GHS Hazard Statement: | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
Precautionary Statement: | P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-113214052-A | Preparation method of 9-hydroxy phenanthrene | 20210512 |
CN-113004340-A | Metal complex, organic electroluminescent material and organic electroluminescent element comprising the same | 20210316 |
CN-112625010-A | 9-hydroxy phenanthrenequinone derivative and preparation method and application thereof | 20201231 |
CN-112521365-A | Phenanthrene ketal with novel structure and degradation method thereof | 20201106 |
CN-112126941-A | Polysubstituted 10-hydroxy phenanthrene derivative and preparation method thereof | 20200922 |
PMID | Publication Date | Title | Journal |
33049310 | 20210401 | Evaluation of a multiplexed, multispecies nuclear receptor assay for chemical hazard assessment | Toxicology in vitro : an international journal published in association with BIBRA |
31054354 | 20190915 | Transient receptor potential melastatin 4 contributes to early-stage endothelial injury induced by arsenic trioxide | Toxicology letters |
27137136 | 20160620 | Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6 | Chemical research in toxicology |
26791488 | 20160401 | Novel regulatory mechanism in human urinary bladder: central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function | American journal of physiology. Cell physiology |
25370840 | 20150201 | Increased micronucleus, nucleoplasmic bridge, and nuclear bud frequencies in the peripheral blood lymphocytes of diesel engine exhaust-exposed workers | Toxicological sciences : an official journal of the Society of Toxicology |
Complexity: | 225 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 194.073164938 |
Formal Charge: | 0 |
Heavy Atom Count: | 15 |
Hydrogen Bond Acceptor Count: | 1 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 194.073164938 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 20.2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 3.6 |
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