TMB 8 hydrochloride - CAS 53464-72-5
Catalog: |
BB028235 |
Product Name: |
TMB 8 hydrochloride |
CAS: |
53464-72-5 |
Synonyms: |
8-(diethylamino)octyl 3,4,5-trimethoxybenzoate;hydrochloride |
Related CAS: | 57818-92-5
|
IUPAC Name: | 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate;hydrochloride |
Description: | TMB 8 is a PKC inhibitor and intracellular calcium antagonist. It also acts as a noncompetitive, functional antagonist at diverse nicotinic acetylcholine receptor (nAChR) subtypes. |
Molecular Weight: | 431.99 |
Molecular Formula: | C22H38ClNO5 |
Canonical SMILES: | CCN(CC)CCCCCCCCOC(=O)C1=CC(=C(C(=C1)OC)OC)OC.Cl |
InChI: | InChI=1S/C22H37NO5.ClH/c1-6-23(7-2)14-12-10-8-9-11-13-15-28-22(24)18-16-19(25-3)21(27-5)20(17-18)26-4;/h16-17H,6-15H2,1-5H3;1H |
InChI Key: | KFJZVXKPPQIYCG-UHFFFAOYSA-N |
Boiling Point: | 461.2 ℃ at 760 mmHg |
Melting Point: | 88-89 ℃ |
Purity: | ≥ 98 % |
Density: | 1.018 g/cm3 |
Appearance: | Solid powder |
LogP: | 5.35360 |
Publication Number | Title | Priority Date |
CA-3031818-A1 | Compounds and methods of promoting myelination | 20160727 |
US-2018228743-A1 | Compounds and methods of promoting myelination | 20160727 |
US-2019269670-A1 | Compounds and methods of promoting myelination | 20160727 |
EP-3838287-A2 | Compounds and methods of promoting myelination | 20160727 |
US-2020046693-A1 | Compositions and methods for the treatment of zellweger spectrum disorder | 20160614 |
PMID | Publication Date | Title | Journal |
20796022 | 20100901 | Calcium dependence of the priming, activation and inactivation of ryanodine receptors in frog motor nerve terminals | The European journal of neuroscience |
19734910 | 20091001 | Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum | Nature chemical biology |
18993082 | 20090301 | Signal transduction in electrically stimulated articular chondrocytes involves translocation of extracellular calcium through voltage-gated channels | Osteoarthritis and cartilage |
17599827 | 20071001 | Involvement of protein kinase C and IP3-mediated Ca2+ release in activity modulation by paraoxon in snail neurons | European journal of pharmacology |
16157373 | 20051201 | Type-3 ryanodine receptor involved in Ca2+-induced Ca2+ release and transmitter exocytosis at frog motor nerve terminals | Cell calcium |
Complexity: | 388 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 2 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 431.2438509999999 |
Formal Charge: | 0 |
Heavy Atom Count: | 29 |
Hydrogen Bond Acceptor Count: | 6 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 431.2438509999999 |
Rotatable Bond Count: | 16 |
Topological Polar Surface Area: | 57.2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
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