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| Description: | 7-O-(Triethylsilyl)-2'-O-tert-butyl(dimethyl)silyl-isocephalomannine is an intermediate used in the synthesis of Iso Cephalomannine (I789500), which is a Cephalomannine (C258500) isomer as an impurity in Paclitaxel (P132500) active pharmaceutical ingredient. Paclitaxel impurity A. It binds to the N-terminal 31 amino acids of the beta-tubulin subunit in the microtubule, rather than to tubulin dimers. Paclitaxel - impurity A. |
| Molecular Weight: | 1060.42 |
| Molecular Formula: | C57H81NO14Si2 |
| References: | Kerns, E., et al. Drug Info J., 32, 471 (1998), Darrington, R., et al. J. Pharm. Sci., 93, 838 (2004),. |
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