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| IUPAC Name: | 7-methoxy-6-(3-morpholin-4-ylpropoxy)-3H-quinazolin-4-one |
| Description: | 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one is an intermediate of Gefitinib. Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. |
| Molecular Weight: | 319.36 |
| Molecular Formula: | C16H21N3O4 |
| Canonical SMILES: | COC1=C(C=C2C(=C1)N=CNC2=O)OCCCN3CCOCC3 |
| InChI: | InChI=1S/C16H21N3O4/c1-21-14-10-13-12(16(20)18-11-17-13)9-15(14)23-6-2-3-19-4-7-22-8-5-19/h9-11H,2-8H2,1H3,(H,17,18,20) |
| InChI Key: | WFUBWLXSYCFZEH-UHFFFAOYSA-N |
| Boiling Point: | 519.5±60.0 °C at 760 mmHg |
| Melting Point: | >243°C (dec.) |
| Density: | 1.32±0.1 g/cm3 |
| Solubility: | Soluble in DMSO (Slightly), Methanol (Slightly) |
| Appearance: | White to Off-white Solid |
| Storage: | Store at 2-8°C |
| LogP: | 0.97070 |
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Morpholines/Thiomorpholines
2,2-Difluoro-N-(2-morpholin-4-ylethyl)ethanamine dihydrochloride
Ethyl 1-methyl-3-(morpholin-4-ylcarbonyl)pyrazole-5-carboxylate
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