7-Azaindole - CAS 271-63-6

Catalog:	BB019487
Product Name:	7-Azaindole
CAS:	271-63-6
Synonyms:	1H-pyrrolo[2,3-b]pyridine

Technical Data

Safety and Hazards

Patents

Literatures

Computed Properties

IUPAC Name:	1H-pyrrolo[2,3-b]pyridine
Description:	Imidazolinone derivatives as CGRP receptor antagonists used in the treatment of migraine.
Molecular Weight:	118.14
Molecular Formula:	C7H6N2
Canonical SMILES:	C1=CC2=C(NC=C2)N=C1
InChI:	InChI=1S/C7H6N2/c1-2-6-3-5-9-7(6)8-4-1/h1-5H,(H,8,9)
InChI Key:	MVXVYAKCVDQRLW-UHFFFAOYSA-N
Boiling Point:	270 °C
Purity:	97%
MDL:	MFCD00005606
LogP:	1.56290

Publication Number	Title	Priority Date
US-10988479-B1	Morphic forms of trilaciclib and methods of manufacture thereof	20200615
EP-3858438-A1	3,4-dihydro-2h-spiro[isoquinoline-1,4'-piperidin]amide derivatives having multimodal activity against pain	20200203
EP-3858439-A1	Amide derivatives having multimodal activity against pain	20200203
EP-3858810-A1	Dialkylaminoarylcycloalkylamide derivatives having multimodal activity against pain	20200203
WO-2021144287-A1	3-benzoyl-1h-pyrrolo[2,3-b]pyridine derivatives as mkk4 inhibitors for treating liver diseases	20200115

PMID	Publication Date	Title	Journal
32787140	20200910	Development of Potent PfCLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials	Journal of medicinal chemistry
31136173	20190627	Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity	Journal of medicinal chemistry
24225656	20140114	The acid-catalysed synthesis of 7-azaindoles from 3-alkynyl-2-aminopyridines and their antimicrobial activity	Organic & biomolecular chemistry
23051946	20121128	Synthesis of functionalized 2-aryl-4-(indol-3-yl)-4H-chromenes via iodine-catalyzed domino Michael addition-intramolecular cyclization reaction	Organic & biomolecular chemistry
22925984	20121101	Spectroscopic study of the ground and excited state prototropic equilibria of 4-azaindole	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

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Related Functional Groups

Azaindoles

[1310704-15-4]
Ethyl 4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate
[885500-55-0]
Ethyl 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylate
[55052-28-3]
4-Chloro-7-azaindole
[346599-62-0]
4-chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one
[1260671-83-7]
4-chloro-1H,2H,3H-pyrrolo[2,3-c]pyridin-2-one
[1477532-48-1]
5-Bromo-4-chloro-3-nitro-1H-pyrrolo[2,3-b]pyridine

Indoles

[1884330-89-5]
1-Methyl-1H-indole-5-D
[116952-58-0]
2-Ethoxycarbonyl-5-methoxytryptamine
[2170450-99-2]
4-Methyl-1-(phenylsulfonyl)-1H-indole-2-carbonitrile
[109021-59-2]
7-Methoxy-1H-indole-3-carbaldehyde
[365547-91-7]
Ethyl 2-amino-5-chloro-1H-indole-3-carboxylate
[6960-46-9]
Ethyl 7-nitroindole-2-carboxylate

GHS Hazard Statement:	H302 (73.33%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (73.33%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (26.67%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (93.33%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement:	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Signal Word:	Danger

Complexity:	103
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	118.0530982
Formal Charge:	0
Heavy Atom Count:	9
Hydrogen Bond Acceptor Count:	1
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	118.0530982
Rotatable Bond Count:	0
Topological Polar Surface Area:	28.7
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	1.8