6-Hydroxydopamine hydrobromide - CAS 636-00-0

Name: 6-Hydroxydopamine hydrobromide
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB032210
Product Name:	6-Hydroxydopamine hydrobromide
CAS:	636-00-0
Synonyms:	Oxidopamine hydrobromide; 2,4,5-Trihydroxyphenethylamine hydrobromide; 6-OHDA HBr
Application:	Labelled Acetophenazine (A163930). Antipsychotic.

Technical Data

Related CAS:	1199-18-4 (free base)
IUPAC Name:	5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide
Description:	6-Hydroxydopamine hydrobromide is a selective catecholaminergic neurotoxin. 6-Hydroxydopamine hydrobromide is used to produce animal model of Parkinson's disease via causing almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats.
Molecular Weight:	250.09
Molecular Formula:	C8H12BrNO3
Canonical SMILES:	C1=C(C(=CC(=C1O)O)O)CCN.Br
InChI:	InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChI Key:	MLACDGUOKDOLGC-UHFFFAOYSA-N
Boiling Point:	406 °C at 760 mmHg
Melting Point:	221-224 °C
Purity:	99%
Solubility:	Soluble in DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Appearance:	Light Brown to Dark Grey Solid
Storage:	Store at -20°C
MDL:	MFCD00012894
LogP:	1.96300

GHS Hazard Statement:	H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement:	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word:	Warning

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PMID	Publication Date	Title	Journal
33571554	20210501	Cystic fibrosis transmembrane conductance regulator-associated ligand protects dopaminergic neurons by differentially regulating metabotropic glutamate receptor 5 in the progression of neurotoxin 6-hydroxydopamine-induced Parkinson's disease model	Neurotoxicology
33486071	20210227	Protection of 6-OHDA neurotoxicity by PGF2α through FP-ERK-Nrf2 signaling in SH-SY5Y cells	Toxicology
32167238	20200801	Protective effects of valproic acid on 6-hydroxydopamine-induced neuroinjury	Environmental toxicology
31705926	20200201	Upregulation of OPA1 by carnosic acid is mediated through induction of IKKγ ubiquitination by parkin and protects against neurotoxicity	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
31778666	20200105	MiR-107 overexpression attenuates neurotoxicity induced by 6-hydroxydopamine both in vitro and in vivo	Chemico-biological interactions

Complexity:	142
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	2
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	249.00006
Formal Charge:	0
Heavy Atom Count:	13
Hydrogen Bond Acceptor Count:	4
Hydrogen Bond Donor Count:	5
Isotope Atom Count:	0
Monoisotopic Mass:	249.00006
Rotatable Bond Count:	2
Topological Polar Surface Area:	86.7 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0