Description: | 6-Ethyl-4-(1-piperazinyl)thieno[2,3-d]pyrimidine Hydrochloride is an intermediate used in the synthesis of 6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride (E926745), which is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation. |
Molecular Weight: | 248.35 + 2(36.46) |
Molecular Formula: | C12H16N4S·2(HCl) |
Solubility: | Methanol |
Appearance: | White Solid |
Storage: | 4°C, Inert atmosphere |
References: | Grembecka, J. et al. Nat. Chem. Biol., 8, 277 (2012). |
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