6-Aminoquinazoline - CAS 101421-72-1

Catalog:	BB000506
Product Name:	6-Aminoquinazoline
CAS:	101421-72-1
Synonyms:	6-quinazolinamine; quinazolin-6-amine

Technical Data

Safety and Hazards

Patents

Literatures

Computed Properties

IUPAC Name:	quinazolin-6-amine
Description:	6-Aminoquinazoline has an effect on TRPC1-mediated neuronal store-operated Ca entry pathway, which delayed the progression of Huntington's disease motor phenotype in Drosophila, making it a therapeutic target for Huntington's disease treatment.
Molecular Weight:	145.16
Molecular Formula:	C8H7N3
Canonical SMILES:	C1=CC2=NC=NC=C2C=C1N
InChI:	InChI=1S/C8H7N3/c9-7-1-2-8-6(3-7)4-10-5-11-8/h1-5H,9H2
InChI Key:	XFGPXURFKAUHQR-UHFFFAOYSA-N
Boiling Point:	335.9 ℃ at 760 mmHg
Density:	1.292 g/cm³
MDL:	MFCD10697883
LogP:	1.79320

Publication Number	Title	Priority Date
WO-2021202936-A1	Pyrazolylpropanamide compounds and uses thereof for treatment of prostate cancer	20200402
CN-112538072-A	Novel aminopyrimidine EGFR (epidermal growth factor receptor) inhibitor	20190921
CN-112110918-A	Spiro-substituted pyrimido-cyclic compounds, preparation method and medical application thereof	20190621
WO-2020243373-A1	Selective androgen receptor degrader (sard) ligands and methods of use thereof	20190529
WO-2020219417-A1	Galactose-linked multimeric glycomimetic inhibitors of e-selectins, galectin-3, and/or cxcr4 chemokine receptors	20190424

PMID	Publication Date	Title	Journal
21510893	20110421	Specific PKC isoforms regulate LPS-stimulated iNOS induction in murine microglial cells	Journal of neuroinflammation
21931671	20110101	Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy	PloS one
21203444	20101223	Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae	PloS one
16428934	20060201	The combi-targeting concept: evidence for the formation of a novel inhibitor in vivo	Anti-cancer drugs
15982640	20050815	Mechanism of action of a novel 'combi-triazene' engineered to possess a polar functional group on the alkylating moiety: evidence for enhancement of potency	Biochemical pharmacology

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Related Functional Groups

Amines and Anilines

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GHS Hazard Statement:	H302+H312+H332 (100%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement:	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Signal Word:	Warning

Complexity:	137
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	145.063997236
Formal Charge:	0
Heavy Atom Count:	11
Hydrogen Bond Acceptor Count:	3
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	145.063997236
Rotatable Bond Count:	0
Topological Polar Surface Area:	51.8
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	0.3