6-Aminophenanthridine - CAS 832-68-8
Catalog: |
BB037000 |
Product Name: |
6-Aminophenanthridine |
CAS: |
832-68-8 |
Synonyms: |
6-phenanthridinamine; phenanthridin-6-amine |
IUPAC Name: | phenanthridin-6-amine |
Description: | 6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz. |
Molecular Weight: | 194.23 |
Molecular Formula: | C13H10N2 |
Canonical SMILES: | C1=CC=C2C(=C1)C3=CC=CC=C3N=C2N |
InChI: | InChI=1S/C13H10N2/c14-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)15-13/h1-8H,(H2,14,15) |
InChI Key: | FVCXJXKLDUJOFA-UHFFFAOYSA-N |
Boiling Point: | 406.4 ℃ at 760 mmHg |
Purity: | ≥ 95 % |
Density: | 1.268 g/cm3 |
Appearance: | Solid powder |
LogP: | 2.90030 |
GHS Hazard Statement: | H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] |
Precautionary Statement: | P264, P264+P265, P270, P280, P301+P316, P305+P351+P338, P321, P330, P337+P317, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
CN-110804053-A | Electronic transmission material of imidazoazacycle and preparation method and application thereof | 20191121 |
CN-110804053-B | Electronic transmission material of imidazoazacycle and preparation method and application thereof | 20191121 |
WO-2021005189-A1 | Novel pfar-inhibiting compounds | 20190709 |
EP-3757100-A1 | Triazine compounds substituted with bulky groups | 20190625 |
WO-2020260406-A1 | Triazine compounds substituted with bulky groups | 20190625 |
PMID | Publication Date | Title | Journal |
21396977 | 20110601 | Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding | Biochimie |
21567961 | 20110601 | The various facets of the protein-folding activity of the ribosome | Biotechnology journal |
21204267 | 20110101 | Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy | EMBO molecular medicine |
20092293 | 20100217 | Synthesis of conjugates of 6-aminophenanthridine and guanabenz, two structurally unrelated prion inhibitors, for the determination of their cellular targets by affinity chromatography | Bioconjugate chemistry |
18683165 | 20080801 | Tools for the study of ribosome-borne protein folding activity | Biotechnology journal |
Complexity: | 229 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 194.084398327 |
Formal Charge: | 0 |
Heavy Atom Count: | 15 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 194.084398327 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 38.9 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 3.1 |
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