5-Methylcytidine - CAS 2140-61-6

Name: 5-Methylcytidine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB016821
Product Name:	5-Methylcytidine
CAS:	2140-61-6
Synonyms:	5-Me-rC; 5-Methyl-cytidine; 4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one; NSC 363933; 5-Methyl-D-cytidine; 5-Methyl-ribo Cytidine

Technical Data

IUPAC Name:	4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one
Description:	5-Methylcytidine is a derivative of Cytidine, found in ribonucleic acids of animals, plants and bacteria. 5-Methylcytidine is a nucleoside found in liver emulsion that can inhibit the growth of spontaneous tumors of mammary gland origin in mice. 5-Methylcytidine is one of many nucleosides that can be used as biomedical marker using liquid chromatography and ion trap mass spectrometry coupling.
Molecular Weight:	257.24
Molecular Formula:	C10H15N3O5
Canonical SMILES:	CC1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
InChI:	InChI=1S/C10H15N3O5/c1-4-2-13(10(17)12-8(4)11)9-7(16)6(15)5(3-14)18-9/h2,5-7,9,14-16H,3H2,1H3,(H2,11,12,17)/t5-,6-,7-,9-/m1/s1
InChI Key:	ZAYHVCMSTBRABG-JXOAFFINSA-N
Boiling Point:	537.5±60.0 °C (Predicted)
Melting Point:	212-215 °C (dec.)
Purity:	≥98% by HPLC
Density:	1.79±0.1 g/cm³
Solubility:	Soluble in DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
Appearance:	Off-white to pale beige solid
Storage:	Store at 2-8 °C, under inert atmosphere
MDL:	MFCD00006548
LogP:	-1.67340

Publication Number	Title	Priority Date
CN-113151481-A	Application of biomarker in esophageal squamous carcinoma differentiation grade evaluation	20210413
CN-113244261-A	Application of CAP activated physiological saline in cell metabolism regulation and tumor treatment and medicine	20210326
CN-112941105-A	Gene modification method of YTHDF2 of m6A 'reader' and application thereof	20210208
CN-112675188-A	Application of 5-Methylcytidine in preparation of spermatogenic promoting drugs	20210112
CN-112858499-A	Method for simultaneously determining modified nucleoside and creatinine in urine	20201231

PMID	Publication Date	Title	Journal
23544149	20130101	DNA methylation program in developing hippocampus and its alteration by alcohol	PloS one
22197484	20121101	Contribution of AT-, GC-, and methylated cytidine-rich DNA to chromatin composition in Malpighian tubule cell nuclei of Panstrongylus megistus (Hemiptera, Reduviidae)	Acta histochemica
22919049	20121001	Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway	RNA (New York, N.Y.)
21764481	20120801	Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction	Neurobiology of aging
22272625	20120601	Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction	Current Alzheimer research

Complexity:	422
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	4
Defined Bond Stereocenter Count:	0
Exact Mass:	257.10117059
Formal Charge:	0
Heavy Atom Count:	18
Hydrogen Bond Acceptor Count:	5
Hydrogen Bond Donor Count:	4
Isotope Atom Count:	0
Monoisotopic Mass:	257.10117059
Rotatable Bond Count:	2
Topological Polar Surface Area:	129
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	-2