5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride - CAS 64821-19-8
Catalog: |
BB032557 |
Product Name: |
5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride |
CAS: |
64821-19-8 |
Synonyms: |
5-[[methyl(prop-2-ynyl)amino]methyl]-8-quinolinol;dihydrochloride; 5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-ol;dihydrochloride |
IUPAC Name: | 5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-ol;dihydrochloride |
Description: | M 30 dihydrochloride is a potent and brain selective inhibitor of monoamine oxidase (MAO) with EC50 values of 37 and 57 nM for MAO-A and MAO-B, respectively. M 30 decreases cell death rates and apoptotic DNA damage, exhibiting neuroprtective properties. |
Molecular Weight: | 299.20 |
Molecular Formula: | C14H16Cl2N2O |
Canonical SMILES: | CN(CC#C)CC1=C2C=CC=NC2=C(C=C1)O.Cl.Cl |
InChI: | InChI=1S/C14H14N2O.2ClH/c1-3-9-16(2)10-11-6-7-13(17)14-12(11)5-4-8-15-14;;/h1,4-8,17H,9-10H2,2H3;2*1H |
InChI Key: | XJNICPXVRPOSSO-UHFFFAOYSA-N |
Purity: | ≥ 98 % by HPLC |
LogP: | 3.60940 |
GHS Hazard Statement: | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation] |
Precautionary Statement: | P264, P264+P265, P270, P280, P301+P317, P305+P354+P338, P317, P330, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
CA-2985344-A1 | Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells | 20140626 |
EP-3160503-A1 | Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells | 20140626 |
US-10487314-B2 | Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells | 20140626 |
US-2017204375-A1 | Inhibition of Serotonin Expression in Gut Enteroendocrine Cells Results in Conversion to Insulin-Positive Cells | 20140626 |
US-2020048615-A1 | Inhibition of Serotonin Expression in Gut Enteroendocrine Cells Results in Conversion to Insulin-Positive Cells | 20140626 |
Complexity: | 296 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 3 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 298.0639685 |
Formal Charge: | 0 |
Heavy Atom Count: | 19 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 3 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 298.0639685 |
Rotatable Bond Count: | 3 |
Topological Polar Surface Area: | 36.4 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
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Related Functional Groups
Quinoline/Isoquinoline
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