5-Hydroxy-7-azaindole - CAS 98549-88-3
Catalog: |
BB042185 |
Product Name: |
5-Hydroxy-7-azaindole |
CAS: |
98549-88-3 |
Synonyms: |
1H-pyrrolo[2,3-b]pyridin-5-ol; 1H-pyrrolo[2,3-b]pyridin-5-ol |
IUPAC Name: | 1H-pyrrolo[2,3-b]pyridin-5-ol |
Description: | 5-Hydroxy-7-azaindole (CAS# 98549-88-3) is a reagent used in the synthesis of potent VEGFR-2 inhibitors. 7-Azaindole derivative identified as an intermediate in the synthesis of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. |
Molecular Weight: | 134.14 |
Molecular Formula: | C7H6N2O |
Canonical SMILES: | C1=CNC2=NC=C(C=C21)O |
InChI: | InChI=1S/C7H6N2O/c10-6-3-5-1-2-8-7(5)9-4-6/h1-4,10H,(H,8,9) |
InChI Key: | VUQZKLXKFUBWRP-UHFFFAOYSA-N |
Density: | 1.434 g/cm3 |
MDL: | MFCD08272242 |
LogP: | 1.26850 |
GHS Hazard Statement: | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P264, P270, P301+P312, P330, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-112939968-A | Preparation method of 5-hydroxy-7-azaindole | 20210203 |
CN-111777626-A | Venetian-dihydroartemisinin split compound and preparation and application thereof | 20200622 |
CN-111777626-B | Venetian-dihydroartemisinin split compound and preparation and application thereof | 20200622 |
CN-110878098-A | Preparation method of BCL-2 inhibitor-vetila | 20191209 |
CN-110922404-A | Process for preparing 5-hydroxy-7-azaindoles | 20191122 |
Complexity: | 129 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 134.048012819 |
Formal Charge: | 0 |
Heavy Atom Count: | 10 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 2 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 134.048012819 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 48.9 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 1 |
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