5-Fluoro-2-oxindole - CAS 56341-41-4
Catalog: |
BB029335 |
Product Name: |
5-Fluoro-2-oxindole |
CAS: |
56341-41-4 |
Synonyms: |
2H-Indol-2-one, 5-fluoro-1,3-dihydro-; 5-Fluoro-1,3-dihydro-2H-indol-2-one; 5-Fluoro-2,3-dihydro-2-oxoindole; 5-Fluoro-2,3-dihydroindol-2-one; 5-Fluoro-2-oxoindoline; 5-Fluoroindolin-2-one; 5-Fluorooxindole |
Related CAS: | 1504576-69-5 (Deleted CAS)
|
IUPAC Name: | 5-fluoro-1,3-dihydroindol-2-one |
Description: | 5-Fluoro-2-oxindole is an impurity of Sunitinib, which is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). |
Molecular Weight: | 151.14 |
Molecular Formula: | C8H6FNO |
Canonical SMILES: | C1C2=C(C=CC(=C2)F)NC1=O |
InChI: | InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11) |
InChI Key: | DDIIYGHHUMKDGI-UHFFFAOYSA-N |
Boiling Point: | 307.2±42.0°C at 760 mmHg |
Melting Point: | 143-144°C |
Purity: | ≥95% |
Density: | 1.311±0.06 g/cm3 |
Solubility: | Soluble in Chloroform (Slightly), Methanol (Slightly) |
Appearance: | Off-white to Beige Solid |
Storage: | Store at 2-8°C |
MDL: | MFCD02179598 |
LogP: | 1.45830 |
GHS Hazard Statement: | H301 (80.56%): Toxic if swallowed [Danger Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
US-2021170039-A1 | Dendrimer compositions and methods for drug delivery to the eye | 20191204 |
WO-2021113662-A2 | Dendrimer compositions and methods for drug delivery to the eye | 20191204 |
WO-2021016102-A1 | Inhibitors of tyrosine kinase | 20190719 |
WO-2020070332-A1 | Oxindole compounds for use as map4k1 inhibitors | 20181005 |
WO-2020056634-A1 | Pyrrole-substituted indolone derivative or pharmaceutically acceptable salt thereof, and preparation method therefor and application thereof | 20180919 |
PMID | Publication Date | Title | Journal |
22346926 | 20120201 | (Z)-2-(5-Fluoro-2-oxoindolin-3-yl-idene)-N-phenyl-hydrazinecarbothio-amide | Acta crystallographica. Section E, Structure reports online |
22019188 | 20111201 | Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents | European journal of medicinal chemistry |
22260025 | 20111101 | [Synthesis and biological evaluation of 3-aromatic Shiff base-5-fluoroindol-2-one derivatives] | Yao xue xue bao = Acta pharmaceutica Sinica |
21264120 | 20100401 | Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one | Journal of young pharmacists : JYP |
21581718 | 20081203 | (Z)-5-Fluoro-3-[(1H-pyrrol-2-yl)methyl-ene]indolin-2-one | Acta crystallographica. Section E, Structure reports online |
Complexity: | 183 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 151.043341977 |
Formal Charge: | 0 |
Heavy Atom Count: | 11 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 151.043341977 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 29.1 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 1.3 |
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