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| IUPAC Name: | 5-(difluoromethyl)-2-hydroxy-6-oxo-1H-pyridine-3-carboxamide |
| Description: | 5-(Difluoromethyl)-2-hydroxy-6-oxo-1,6-dihydropyridine-3-carboxamide is a building block related to Favipiravir(F103350). Favipiravir is used for the treatment of advanced Ebola virus infection in a small animal model. Favipiravir suppressed the replication of Zaire Ebola virus and prevented a lethal outcome in 100% of the animals. Based on the studies, Favipiravir can be a candidate for the treatment of Ebola hemorrhagic fever. |
| Molecular Weight: | 204.13 |
| Molecular Formula: | C7H6F2N2O3 |
| Canonical SMILES: | C1=C(C(=O)NC(=C1C(=O)N)O)C(F)F |
| InChI: | InChI=1S/C7H6F2N2O3/c8-4(9)2-1-3(5(10)12)7(14)11-6(2)13/h1,4H,(H2,10,12)(H2,11,13,14) |
| InChI Key: | MDVTZHBUCUIHHA-UHFFFAOYSA-N |
| References: | Oestereich, L., et al. Antiviral Res., 105, 17 (2014); Baranovich, T., et al. J. Virol. 87, 3741 (2013); Chem. and Eng. News p.8, Dec. 1 (2014). |
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