5-Chlorothiophene-2-sulfonyl chloride - CAS 2766-74-7
Catalog: |
BB019633 |
Product Name: |
5-Chlorothiophene-2-sulfonyl chloride |
CAS: |
2766-74-7 |
Synonyms: |
5-chlorothiophene-2-sulfonyl chloride |
IUPAC Name: | 5-chlorothiophene-2-sulfonyl chloride |
Description: | 5-Chlorothiophene-2-sulfonyl chloride (CAS# 2766-74-7) is a sulfonylthiophene derivative used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease. |
Molecular Weight: | 217.09 |
Molecular Formula: | C4H2Cl2O2S2 |
Canonical SMILES: | C1=C(SC(=C1)Cl)S(=O)(=O)Cl |
InChI: | InChI=1S/C4H2Cl2O2S2/c5-3-1-2-4(9-3)10(6,7)8/h1-2H |
InChI Key: | SORSTNOXGOXWAO-UHFFFAOYSA-N |
Boiling Point: | 112-117 °C |
Density: | 1.623 g/cm3 |
MDL: | MFCD00051667 |
LogP: | 3.40980 |
GHS Hazard Statement: | H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] |
Precautionary Statement: | P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
CN-111763201-A | Benzothiazole compound and medical application thereof | 20200303 |
CN-112812111-A | Benzothiazole compound and medical application thereof | 20200303 |
WO-2021175234-A1 | Benzothiazole compound and medical use | 20200303 |
WO-2021123237-A1 | 2-amino-n-(amino-oxo-aryl-lambda6-sulfanylidene)acetamide compounds and their therapeutic use | 20191219 |
CN-112409223-A | Amide compounds and medical application thereof as STING inhibitor | 20191012 |
Complexity: | 208 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 215.8873270 |
Formal Charge: | 0 |
Heavy Atom Count: | 10 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 215.8873270 |
Rotatable Bond Count: | 1 |
Topological Polar Surface Area: | 70.8 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 2.9 |
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