5-Bromo-7-azaindole - CAS 183208-35-7
Catalog: |
BB014041 |
Product Name: |
5-Bromo-7-azaindole |
CAS: |
183208-35-7 |
Synonyms: |
5-bromo-1H-pyrrolo[2,3-b]pyridine |
IUPAC Name: | 5-bromo-1H-pyrrolo[2,3-b]pyridine |
Description: | 5-Bromo-7-azaindole (CAS# 183208-35-7) is a chemical reagent used in organic syntheses. Used in the synthesis of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. Also used in other 7-azaindole derivatives such as for PDK1 inihibtors. |
Molecular Weight: | 197.03 |
Molecular Formula: | C7H5BrN2 |
Canonical SMILES: | C1=CNC2=NC=C(C=C21)Br |
InChI: | InChI=1S/C7H5BrN2/c8-6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10) |
InChI Key: | LPTVWZSQAIDCEB-UHFFFAOYSA-N |
Purity: | 97.0 % |
Density: | 1.77 g/cm3 |
MDL: | MFCD06659677 |
LogP: | 2.32540 |
GHS Hazard Statement: | H302 (87.76%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
CN-113321650-A | 3-substituent-5- (substituted aryl) -7-azaindole derivative and application thereof | 20210520 |
CN-112939968-A | Preparation method of 5-hydroxy-7-azaindole | 20210203 |
CN-111848607-A | Novel BCL-2/BCL-XL inhibitor, pharmaceutical composition and application | 20200722 |
CN-111662288-A | Small molecular compound for inhibiting AKT and STAT3 activities and application thereof | 20200623 |
WO-2021208963-A1 | Bcl-2 inhibitor | 20200415 |
Complexity: | 129 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 195.96361 |
Formal Charge: | 0 |
Heavy Atom Count: | 10 |
Hydrogen Bond Acceptor Count: | 1 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 195.96361 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 28.7 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 2 |
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Related Functional Groups
Azaindoles
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