5-Amino-2-methoxypyridine - CAS 6628-77-9

Name: 5-Amino-2-methoxypyridine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB032973
Product Name:	5-Amino-2-methoxypyridine
CAS:	6628-77-9
Synonyms:	3-Pyridinamine, 6-methoxy-; 6-Methoxy-3-pyridinamine; Pyridine, 5-amino-2-methoxy-; (2-Methoxypyridin-5-yl)amine; 2-Methoxy-5-aminopyridine; 2-Methoxypyridin-5-amine; 3-Amino-6-methoxypyridine; 6-Methoxy-3-aminopyridine; 6-Methoxy-3-pyridinylamine; NSC 59708

Technical Data

IUPAC Name:	6-methoxypyridin-3-amine
Description:	5-Amino-2-methoxypyridine is used as a reagent in the synthesis of a novel series of thienopyrimidines as highly potent and selective PI3K inhibitors. It is also used to synthesize EMPA, a novel high-affinity selective antagonist for the OX2 receptor.
Molecular Weight:	124.14
Molecular Formula:	C6H8N2O
Canonical SMILES:	COC1=NC=C(C=C1)N
InChI:	InChI=1S/C6H8N2O/c1-9-6-3-2-5(7)4-8-6/h2-4H,7H2,1H3
InChI Key:	UUVDJIWRSIJEBS-UHFFFAOYSA-N
Boiling Point:	125-126°C
Melting Point:	30°C
Purity:	95%
Density:	1.139±0.06 g/cm3
Solubility:	Soluble in Chloroform, Methanol (Slightly)
Appearance:	Yellow-brown or Red to Very Dark Red Liquid
Storage:	Store at 2-8°C
MDL:	MFCD00006264
LogP:	1.25360

GHS Hazard Statement:	H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
Precautionary Statement:	P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word:	Warning

Publication Number	Title	Priority Date
CN-111732535-A	Photochemical synthesis method of heteroaryl amine compound	20200810
CN-111732535-B	Photochemical synthesis method of heteroaryl amine compound	20200810
CN-111777549-A	Synthesis process of 2-methoxy-3-bromo-5-fluoropyridine	20200707
WO-2021212039-A1	Inhibitors of cysteine proteases and methods of use thereof	20200417
WO-2021164746-A1	Substituted aryl compound	20200219

Complexity:	87.1
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	124.063662883
Formal Charge:	0
Heavy Atom Count:	9
Hydrogen Bond Acceptor Count:	3
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	124.063662883
Rotatable Bond Count:	1
Topological Polar Surface Area:	48.1 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	1