5-Amino-1-methyl-1H-indazole - CAS 50593-24-3
Catalog: |
BB027123 |
Product Name: |
5-Amino-1-methyl-1H-indazole |
CAS: |
50593-24-3 |
Synonyms: |
1-methyl-5-indazolamine; 1-methylindazol-5-amine |
IUPAC Name: | 1-methylindazol-5-amine |
Description: | 5-Amino-1-methyl-1H-indazole (CAS# 50593-24-3) is used in preparation of Hydrazone compounds having (Hetero)aryl group at terminal Amine group for treating tau protein-associated disease. Also, used in preparation of Dihydroisoindole-1H-pyrazolo[3,4-d]pyrimidinone compounds as Wee1 inhibitors for treatment of kinase-related diseases. |
Molecular Weight: | 147.18 |
Molecular Formula: | C8H9N3 |
Canonical SMILES: | CN1C2=C(C=C(C=C2)N)C=N1 |
InChI: | InChI=1S/C8H9N3/c1-11-8-3-2-7(9)4-6(8)5-10-11/h2-5H,9H2,1H3 |
InChI Key: | PYOFNPHTKBSXOM-UHFFFAOYSA-N |
Boiling Point: | 321.6 °C at 760 mmHg |
Density: | 1.27 g/cm3 |
MDL: | MFCD03305455 |
LogP: | 1.73670 |
GHS Hazard Statement: | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-112778125-A | Aryl phenol compound and synthesis method and application thereof | 20210201 |
KR-102178181-B1 | Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof | 20200331 |
KR-20200076655-A | Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof | 20200331 |
WO-2021093795-A1 | Rock inhibitor, preparation method therefor and use thereof | 20191115 |
WO-2021093172-A1 | Hbv inhibitor and use thereof | 20191113 |
PMID | Publication Date | Title | Journal |
21126022 | 20110113 | Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase | Journal of medicinal chemistry |
Complexity: | 148 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 147.079647300 |
Formal Charge: | 0 |
Heavy Atom Count: | 11 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 147.079647300 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 43.8 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 0.9 |
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Amines and Anilines
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