IUPAC Name: | (4R,6S)-4-hydroxy-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide |
Description: | (4R,6S)-rel-5,6-Dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide is used as a reactant in the preparation of Dorzolamide Hydrochloride (D535100), which is a carbonic anhydrase inhibitor; antiglaucoma agent. |
Molecular Weight: | 297.37 |
Molecular Formula: | C8H11NO5S3 |
Canonical SMILES: | CC1CC(C2=C(S1(=O)=O)SC(=C2)S(=O)(=O)N)O |
InChI: | InChI=1S/C8H11NO5S3/c1-4-2-6(10)5-3-7(17(9,13)14)15-8(5)16(4,11)12/h3-4,6,10H,2H2,1H3,(H2,9,13,14)/t4-,6+/m0/s1 |
InChI Key: | ZXSUWHJGLUHKPC-UJURSFKZSA-N |
Melting Point: | 198-199°C |
Solubility: | DMSO (Slightly), Methanol (Slightly) |
Appearance: | Off-White to Pale Beige Solid |
Storage: | -20°C Freezer |
References: | Lippa, E.A., et al. Ophthalmology, 98, 308 (1991); Wang, R.-F., et al. Arch. Ophthalmol., 109, 1297 (1991); Whikehart, D., et al. J. Ocul. Pharmacol., 7, 195 (1991); Sjoquist, B., et al. Drug Metab. Dispos., 26, 745 (1998). |
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