4-Quinolinol - CAS 611-36-9
Catalog: |
BB030968 |
Product Name: |
4-Quinolinol |
CAS: |
611-36-9 |
Synonyms: |
1H-quinolin-4-one |
IUPAC Name: | 1H-quinolin-4-one |
Description: | 4-Hydroxyquinolineis a hydroxylated quinoline derivative with antimicrobial activity. 4-Hydroxyquinoline showed growth-inhibitory effects against intestinal bacteria. 4-Hydroxyquinoline act as sacrificial scavengers of the photogenerated oxygen species and has been shown to prevent the photodegradation of riboflavin. |
Molecular Weight: | 145.16 |
Molecular Formula: | C9H7NO |
Canonical SMILES: | C1=CC=C2C(=C1)C(=O)C=CN2 |
InChI: | InChI=1S/C9H7NO/c11-9-5-6-10-8-4-2-1-3-7(8)9/h1-6H,(H,10,11) |
InChI Key: | PMZDQRJGMBOQBF-UHFFFAOYSA-N |
Boiling Point: | 261.5 °C at 760 mmHg |
Purity: | 98 % |
Density: | 1.188 g/cm3 |
Appearance: | Light beige to yellowish cryst. powder or needles |
MDL: | MFCD00006777 |
LogP: | 1.94040 |
GHS Hazard Statement: | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] |
Precautionary Statement: | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
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PMID | Publication Date | Title | Journal |
31022492 | 20190615 | HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator | Toxicology and applied pharmacology |
30896932 | 20190415 | Bioactivation of Quinolines in a Recombinant Estrogen Receptor Transactivation Assay Is Catalyzed by N-Methyltransferases | Chemical research in toxicology |
25605352 | 20150401 | Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum | Antimicrobial agents and chemotherapy |
24392742 | 20140124 | 4-Quinolone alkaloids from Melochia odorata | Journal of natural products |
23515079 | 20130320 | Quinolone-3-diarylethers: a new class of antimalarial drug | Science translational medicine |
Complexity: | 198 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 145.052763847 |
Formal Charge: | 0 |
Heavy Atom Count: | 11 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 145.052763847 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 29.1 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 0.6 |
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Quinoline/Isoquinoline
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