4- Hydroxy- 2- (phenylmethyl) isoquinolinium - CAS 438564-84-2

Catalog: BB063981
Product Name: 4- Hydroxy- 2- (phenylmethyl) isoquinolinium
CAS: 438564-84-2
Synonyms: N-Benzyl-4-hydroxyisoquinolinium Chloride
Description:4- Hydroxy- 2- (phenylmethyl) isoquinolinium is an impurity of 1-Phenyl-2,3-dihydroisoquinolin-4(1H)-one Hydrochloride (P309050), which is a useful synthetic intermediate in the synthesis of cis-Hydroxy Solifenacin (H953525) and cis-Hydroxy Solifenacin N-Oxide (H953485); both metabolites of Solifenacin (S676700, HCl) which is a muscarinic M3 receptor antagonist and is used in treatment of urinary incontinence.
Molecular Weight:271.74
Molecular Formula:C16H14ClNO
Solubility:DMSO, Ethyl Acetate, Methanol
Appearance:Off White Solid
References:Naito, R., et al. J. Med. Chem., 48, 6597 (2005); Krauwinkel, W., et al. Int. J. Clin. Pharmacol. Ther., 43, 227 (2005); Ikeda K., et al. Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al. Br. J. Urol., 93, 303 (2004); Ohtake, A., et al. Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al. Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al. Eur. Urol. 47, 376 (2005); Payne, C.K., et al. Drugs, 66, 175 (2006).

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