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| Description: | 4- Hydroxy- 2- (phenylmethyl) isoquinolinium is an impurity of 1-Phenyl-2,3-dihydroisoquinolin-4(1H)-one Hydrochloride (P309050), which is a useful synthetic intermediate in the synthesis of cis-Hydroxy Solifenacin (H953525) and cis-Hydroxy Solifenacin N-Oxide (H953485); both metabolites of Solifenacin (S676700, HCl) which is a muscarinic M3 receptor antagonist and is used in treatment of urinary incontinence. |
| Molecular Weight: | 271.74 |
| Molecular Formula: | C16H14ClNO |
| Solubility: | DMSO, Ethyl Acetate, Methanol |
| Appearance: | Off White Solid |
| References: | Naito, R., et al. J. Med. Chem., 48, 6597 (2005); Krauwinkel, W., et al. Int. J. Clin. Pharmacol. Ther., 43, 227 (2005); Ikeda K., et al. Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al. Br. J. Urol., 93, 303 (2004); Ohtake, A., et al. Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al. Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al. Eur. Urol. 47, 376 (2005); Payne, C.K., et al. Drugs, 66, 175 (2006). |
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