IUPAC Name: | 4-hydroxy-2-methyl-1,1-dioxo-1λ6,2-benzothiazine-3-carboxylic acid |
Description: | 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic Acid, 1,1-Dioxide could be useful in analytical studies that look to enhance chemical stability of drug substances with high melting points by melt extrusion. 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic Acid, 1,1-Dioxide is similar to Methyl 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (M312845(P)), which is an impurity found in Meloxicam (M216100(P)). Meloxicam was specifically used in these melt extrusion studies. |
Molecular Weight: | 255.25 |
Molecular Formula: | C10H9NO5S |
Canonical SMILES: | CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)O |
InChI: | InChI=1S/C10H9NO5S/c1-11-8(10(13)14)9(12)6-4-2-3-5-7(6)17(11,15)16/h2-5,12H,1H3,(H,13,14) |
InChI Key: | HTZOXRHYFAORSJ-UHFFFAOYSA-N |
References: | Haser, A., et al. Int. J. Pharm. (Amsterdam, Neth.), 524, 55 (2017); Lombardino, J., et al. J. Med. Chem., 14, 1171 (1971); Shin, S., et al. Drug Dev. Ind. Pharm., 26, 563 (2000). |
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