4-Chloro-6,7-dimethoxyquinoline - CAS 35654-56-9
Catalog: |
BB022712 |
Product Name: |
4-Chloro-6,7-dimethoxyquinoline |
CAS: |
35654-56-9 |
Synonyms: |
4-chloro-6,7-dimethoxyquinoline; 4-chloro-6,7-dimethoxyquinoline |
IUPAC Name: | 4-chloro-6,7-dimethoxyquinoline |
Description: | 4-Chloro-6,7-dimethoxyquinoline (CAS# 35654-56-9) is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents. |
Molecular Weight: | 223.66 |
Molecular Formula: | C11H10ClNO2 |
Canonical SMILES: | COC1=CC2=C(C=CN=C2C=C1OC)Cl |
InChI: | InChI=1S/C11H10ClNO2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3 |
InChI Key: | WRVHQEYBCDPZEU-UHFFFAOYSA-N |
Boiling Point: | 325.2 °C at 760 mmHg |
Density: | 1.265 g/cm3 |
Appearance: | Pale yellow to beige powder |
MDL: | MFCD07778437 |
LogP: | 2.90540 |
GHS Hazard Statement: | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] |
Precautionary Statement: | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-111960997-A | Method for synthesizing hydroxyalkyl substituted quinoline derivatives | 20200907 |
CN-111960997-B | Method for synthesizing hydroxyalkyl substituted quinoline derivatives | 20200907 |
CN-111423371-A | Synthesis method of cabozantinib dimer | 20200527 |
CN-111518027-A | Preparation method of cabozantinib nitrogen oxide impurity | 20200527 |
CN-111533690-A | Preparation method of cabozantinib defluorinated impurity | 20200527 |
PMID | Publication Date | Title | Journal |
22220029 | 20111101 | 4-Chloro-6,7-dimeth-oxy-quinoline | Acta crystallographica. Section E, Structure reports online |
Complexity: | 215 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 223.0400063 |
Formal Charge: | 0 |
Heavy Atom Count: | 15 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 223.0400063 |
Rotatable Bond Count: | 2 |
Topological Polar Surface Area: | 31.4 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 2.8 |
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Quinoline/Isoquinoline
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