4-Aminobenzoic hydrazide - CAS 5351-17-7

Name: 4-Aminobenzoic hydrazide
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB028252
Product Name:	4-Aminobenzoic hydrazide
CAS:	5351-17-7
Synonyms:	4-Aminobenzhydrazide; 4-Aminobenzoic acid hydrazide; Amben hydrazide

Technical Data

IUPAC Name:	4-aminobenzohydrazide
Description:	4-Aminobenzoic hydrazide is an inhibitor of MPO (Myeloperoxidase) enzyme with an IC50 of 0.3 µM. It is also an intermediate used to prepare phenolic acyl hydrazones as agonists for ERRβ and ERRγ. It is used in the synthesis of 2-(arylpyrazolylaminomethyl)-1,3,4-oxadiazoles as potent antimicrobial and antitubercular agents.
Molecular Weight:	151.17
Molecular Formula:	C7H9N3O
Canonical SMILES:	C1=CC(=CC=C1C(=O)NN)N
InChI:	InChI=1S/C7H9N3O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,8-9H2,(H,10,11)
InChI Key:	WPBZMCGPFHZRHJ-UHFFFAOYSA-N
Melting Point:	225-227 °C
Density:	1.3±0.1 g/cm3
Appearance:	White crystalline powder
MDL:	MFCD00007606
LogP:	1.54470

GHS Hazard Statement:	H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement:	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word:	Warning

Publication Number	Title	Priority Date
US-2020397807-A1	Nicotinyl riboside compounds and their uses	20190618
WO-2020257283-A1	Nicotinyl riboside compounds and their uses	20190618
US-10590326-B1	Storable gas generating compositions	20190221
US-10858565-B2	Gas generating compositions	20190221
US-2020270502-A1	Gas generating compositions	20190221

PMID	Publication Date	Title	Journal
32726580	20200925	Tempol reduces inflammation and oxidative damage in cigarette smoke-exposed mice by decreasing neutrophil infiltration and activating the Nrf2 pathway	Chemico-biological interactions
25614581	20160801	In vitro activation of dibromoacetonitrile to cyanide by myeloperoxidase	Toxicology and industrial health
24530881	20140320	Effect of myeloperoxidase inhibition on gene expression profiles in HL-60 cells exposed to 1,2,4,-benzenetriol	Toxicology
23994743	20131025	7-Hydroxycoumarin modulates the oxidative metabolism, degranulation and microbial killing of human neutrophils	Chemico-biological interactions
24007263	20131002	Beer thiol-containing compounds and redox stability: kinetic study of 1-hydroxyethyl radical scavenging ability	Journal of agricultural and food chemistry

Complexity:	141
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	151.074561919
Formal Charge:	0
Heavy Atom Count:	11
Hydrogen Bond Acceptor Count:	3
Hydrogen Bond Donor Count:	3
Isotope Atom Count:	0
Monoisotopic Mass:	151.074561919
Rotatable Bond Count:	1
Topological Polar Surface Area:	81.1 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	-0.7