4-Amino-2,6-dichloropyrimidine - CAS 10132-07-7

Catalog:	BB000483
Product Name:	4-Amino-2,6-dichloropyrimidine
CAS:	10132-07-7
Synonyms:	2,6-dichloropyrimidin-4-amine

Technical Data

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Computed Properties

IUPAC Name:	2,6-dichloropyrimidin-4-amine
Description:	4-Amino-2,6-dichloropyrimidine (CAS# 10132-07-7) is used in preparation of Tetrazolylphenylbenzylaminopyridine derivatives and analogs for use as Indoleamine 2,3-Dioxygenase inhibitors.
Molecular Weight:	163.99
Molecular Formula:	C4H3Cl2N3
Canonical SMILES:	C1=C(N=C(N=C1Cl)Cl)N
InChI:	InChI=1S/C4H3Cl2N3/c5-2-1-3(7)9-4(6)8-2/h1H,(H2,7,8,9)
InChI Key:	UPVBKNZVOJNQKE-UHFFFAOYSA-N
Boiling Point:	323.5 °C at 760 mmHg
Purity:	97.0 %
Density:	1.606 g/cm³
MDL:	MFCD00038015
LogP:	1.94680

Publication Number	Title	Priority Date
CN-112851587-A	Alkyne heterocyclic compound for treating cancer and preparation method and application thereof	20210121
CN-112457260-A	N-heterocyclic aryl quinazoline-4-amine compound and preparation method thereof	20201208
CN-111848953-A	Preparation method of self-catalytic phthalonitrile resin containing thioether bonds	20200824
US-2021205311-A1	Combination Therapy Comprising A2A/A2B and PD-1/PD-L1 Inhibitors	20200103
US-2021230294-A1	Cd73 inhibitor and a2a/a2b adenosine receptor inhibitor combination therapy	20200103

PMID	Publication Date	Title	Journal
10819436	20000301	Structure-activity relationship studies on potential non-nucleoside DABO-like inhibitors of HIV-1 reverse transcriptase	Antiviral chemistry & chemotherapy

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Related Functional Groups

Amines and Anilines

[1158353-54-8]
(4-Pyrazol-1-ylphenyl)methanamine sulfuric acid
[1006473-17-1]
[(2,3-Difluorophenyl)methyl][(1,3-dimethylpyrazol-4-yl)methyl]amine
[1225940-17-9]
1-(3-Chloro-4-methylphenyl)-3-(trifluoromethyl)pyrazole-5-ylamine
[1431965-90-0]
1-Cyclopentyl-5-methylpyrazol-3-amine hydrochloride
[1082066-00-9]
1-Cyclopropyl-1H-pyrazole-4-carbaldehyde
[1824357-78-9]
2-(1-Benzyl-3-pyrazolyl)ethylamine

GHS Hazard Statement:	H302 (86.96%): Harmful if swallowed [Warning Acute toxicity, oral]
Precautionary Statement:	P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word:	Warning

Complexity:	99.8
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	162.9704025
Formal Charge:	0
Heavy Atom Count:	9
Hydrogen Bond Acceptor Count:	3
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	162.9704025
Rotatable Bond Count:	0
Topological Polar Surface Area:	51.8 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	1.8