(3b)-24-Bromo-3-[(tert-butyl)dimethylsilyloxy]-chol-5-ene - CAS 1384736-07-5

Catalog: BB072288
Product Name: (3b)-24-Bromo-3-[(tert-butyl)dimethylsilyloxy]-chol-5-ene
CAS: 1384736-07-5
Synonyms: (3β)-24-Bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-chol-5-ene
(3b)-24-Bromo-3-[(tert-butyl)dimethylsilyloxy]-chol-5-ene
IUPAC Name:[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-5-bromopentan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy-tert-butyl-dimethylsilane
Description:(3b)-24-Bromo-3-[(tert-butyl)dimethylsilyloxy]-chol-5-ene is a reactant used in the preparation of series of cholesterol side-chain analogs used in studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P 450 enzymes CYP124A1, CYP125A1 and CYP142A1.
Molecular Weight:537.73
Molecular Formula:C30H53BrOSi
Canonical SMILES:CC(CCCBr)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O[Si](C)(C)C(C)(C)C)C)C
InChI:InChI=1S/C30H53BrOSi/c1-21(10-9-19-31)25-13-14-26-24-12-11-22-20-23(32-33(7,8)28(2,3)4)15-17-29(22,5)27(24)16-18-30(25,26)6/h11,21,23-27H,9-10,12-20H2,1-8H3/t21-,23+,24+,25-,26+,27+,29+,30-/m1/s1
InChI Key:GRPMVEFKZYTBJO-NXUCFJMCSA-N
Solubility:Chloroform, Dichloromethane, Ethyl Acetate
Appearance:White Solid
References:Johnston, J. et al. Bioorg. Med. Chem., 20, 4064 (2012).

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