Azetidin-3-ol hydrochloride - CAS 18621-18-6
Catalog: |
BB014284 |
Product Name: |
Azetidin-3-ol hydrochloride |
CAS: |
18621-18-6 |
Synonyms: |
3-Hydroxyazetidine hydrochloride; 3-Hydroxyazetidine HCl; 3-hydroxy-1-azetidine hydrochloride |
IUPAC Name: | azetidin-3-ol;hydrochloride |
Description: | Azetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
Molecular Weight: | 109.55 |
Molecular Formula: | C3H8ClNO |
Canonical SMILES: | C1C(CN1)O.Cl |
InChI: | InChI=1S/C3H7NO.ClH/c5-3-1-4-2-3;/h3-5H,1-2H2;1H |
InChI Key: | UQUPQEUNHVVNKW-UHFFFAOYSA-N |
Boiling Point: | 170.7 °C at 760 mmHg |
Melting Point: | 85-90°C |
Solubility: | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
Appearance: | Off-white to light yellow Solid |
MDL: | MFCD02683887 |
LogP: | 0.08130 |
GHS Hazard Statement: | H302 (85.71%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
CN-112979532-A | Phthalimide compound, preparation method and application | 20210520 |
CN-112979532-B | Phthalimide compound, preparation method and application | 20210520 |
CN-111825592-A | Synthetic method of 3-hydroxyazetidine hydrochloride | 20200728 |
CN-111763236-A | Arenobufagin carbamate derivatives and application thereof | 20200624 |
WO-2021211922-A1 | Spiro-sulfonimidamide derivatives as inhibitors of myeloid cell leukemia-1 (mcl-1) protein | 20200416 |
PMID | Publication Date | Title | Journal |
21192663 | 20110210 | Polyazetidine-coated microelectrodes: electrochemical and diffusion characterization of different redox substrates | The journal of physical chemistry. B |
Complexity: | 33.9 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 2 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 109.0294416 |
Formal Charge: | 0 |
Heavy Atom Count: | 6 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 3 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 109.0294416 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 32.3 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
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