3-(Dimethylphenylsilyl)-cyclobutanone - CAS 847158-84-3

Catalog: BB062813
Product Name: 3-(Dimethylphenylsilyl)-cyclobutanone
CAS: 847158-84-3
Synonyms: 3-(Dimethyl(phenyl)silyl)cyclobutanone
3-(Dimethylphenylsilyl)-cyclobutanone
IUPAC Name:3-[dimethyl(phenyl)silyl]cyclobutan-1-one
Description:3-(Dimethylphenylsilyl)-cyclobutanone is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3β inhibitors as anticancer agents.
Molecular Weight:204.34
Molecular Formula:C12H16OSi
Canonical SMILES:C[Si](C)(C1CC(=O)C1)C2=CC=CC=C2
InChI:InChI=1S/C12H16OSi/c1-14(2,12-8-10(13)9-12)11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3
InChI Key:UCLQUAUTIGIDGZ-UHFFFAOYSA-N
Solubility:Dichloromethane, Ethyl Acetate
Appearance:Pale Yellow Oil
References:Choi, M.J., et al. Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al. Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al. Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al. Org. Biomolec. Chem., 10, 6404 (2012).

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