3-Desaminosulfonyl 2-Aminosulfonyl N-Acetyl Dorzolamide - CAS 403848-30-6

Catalog: BB068461
Product Name: 3-Desaminosulfonyl 2-Aminosulfonyl N-Acetyl Dorzolamide
CAS: 403848-30-6
Synonyms: (4S,6S)-4-(Acetylethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonyl Chloride 7,7-Dioxide
3-Desaminosulfonyl 2-Aminosulfonyl N-Acetyl Dorzolamide
IUPAC Name:(4S,6S)-4-[acetyl(ethyl)amino]-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonyl chloride
Description:3-Desaminosulfonyl 2-Aminosulfonyl N-Acetyl Dorzolamide is an intermediate used in the synthesis of 2-Desaminosulfonyl 3-Aminosulfonyl Dorzolamide (D288235), which is a useful synthetic compound. Also, it is derived from (4R,6S)-5,6-Dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-ol 7,7-Dioxide (T344510), which is an analog of topically-active carbonic anhydrase inhibitor MK-507, commonly known Dorzolamide (D535100).
Molecular Weight:385.91
Molecular Formula:C12H16ClNO5S3
Canonical SMILES:CCN(C1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)Cl)C)C(=O)C
InChI:InChI=1S/C12H16ClNO5S3/c1-4-14(8(3)15)10-5-7(2)21(16,17)12-9(10)6-11(20-12)22(13,18)19/h6-7,10H,4-5H2,1-3H3/t7-,10-/m0/s1
InChI Key:UQKNTDOUGNFSHG-XVKPBYJWSA-N
References:Blacklock, T., et al. J. Org. Chem., 58, 1672 (1993); Tempkin, O., et al. Tetrahedron: Asym., 7, 2721 (1996).

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