3-Bromo-6-chloroimidazo[1,2-b]pyridazine - CAS 13526-66-4
Catalog: |
BB008119 |
Product Name: |
3-Bromo-6-chloroimidazo[1,2-b]pyridazine |
CAS: |
13526-66-4 |
Synonyms: |
3-bromo-6-chloroimidazo[1,2-b]pyridazine; 3-bromo-6-chloroimidazo[1,2-b]pyridazine |
IUPAC Name: | 3-bromo-6-chloroimidazo[1,2-b]pyridazine |
Description: | 3-Bromo-6-chloroimidazo[1,2-b]pyridazine (CAS# 13526-66-4) is a reagent in the synthesis of imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1). |
Molecular Weight: | 232.47 |
Molecular Formula: | C6H3BrClN3 |
Canonical SMILES: | C1=CC(=NN2C1=NC=C2Br)Cl |
InChI: | InChI=1S/C6H3BrClN3/c7-4-3-9-6-2-1-5(8)10-11(4)6/h1-3H |
InChI Key: | PFHPKMPWBFJZEY-UHFFFAOYSA-N |
Density: | 2.03 g/cm3 |
Storage: | Inert atmosphere, 2-8 °C |
LogP: | 2.14520 |
GHS Hazard Statement: | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] |
Precautionary Statement: | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
WO-2021170109-A1 | Tropomyosin receptor kinase (trk) degradation compounds and methods of use | 20200226 |
CN-111226956-A | Application of 3, 6-disubstituted imidazo [1,2-b ] pyridazine derivative in preparation of bactericide | 20191126 |
WO-2021098745-A1 | Preparation and application of a class of protein receptor kinase inhibitors | 20191118 |
US-2020338076-A1 | Formulations comprising heterocyclic protein kinase inhibitors | 20190212 |
WO-2020047037-A1 | Novel heteroaromatic compounds as potent modulators of the hippo-yap signaling pathway lats1/2 kinases | 20180831 |
PMID | Publication Date | Title | Journal |
24035097 | 20131101 | Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues | Bioorganic & medicinal chemistry letters |
Complexity: | 157 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 230.91989 |
Formal Charge: | 0 |
Heavy Atom Count: | 11 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 230.91989 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 30.2 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 2.3 |
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