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| Description: | (3α, 5β) -3- Acetate 17- (3- Pyridinyl) -androst- 16- en- 3- ol is an intermediate in the synthesis of 3-keto-5β-abiraterone (K170985), a metabolite of abiraterone (A108490) which is a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17).3-Keto-5β-abiraterone is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer. |
| Molecular Weight: | 393.56 |
| Molecular Formula: | C26H35NO2 |
| References: | Denis, L., et al. Cancer, 72, 3888 (1993); Potter, G.A., et al. J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al. Nat. Rev., 2, 389 (2002); Scher, H., et al. J. Clin. Oncol., 23, 8253 (2005). |
Catalog: BB012925
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