3,4-Dibenzyloxybenzyl Alcohol - CAS 1699-58-7

Catalog: BB066404
Product Name: 3,4-Dibenzyloxybenzyl Alcohol
CAS: 1699-58-7
Synonyms: 3,4-Bis(Phenylmethoxy)benzenemethanol;1,2-Dibenzyloxy-4-(hydroxymethyl)benzene;3,4-Bisbenzyloxybenzyl Alcohol;NSC 145670;[3,4-Bis(Benzyloxy)phenyl]methanol
3,4-Dibenzyloxybenzyl Alcohol
IUPAC Name:[3,4-bis(phenylmethoxy)phenyl]methanol
Description:3,4-Dibenzyloxybenzyl Alcohol is an intermediate in the synthesis of Dopal (D533885), a product of Dopamine (CAT# D533780) catabolism by monoamine oxidase and may be further oxidized to 3, 4- Dihydroxyphenylacetic Acid (CAT# D454250) via aldehyde dehydrogenase. DOPAL can also be reduced to Hydroxy Tyrosol (CAT# H977000) via cytosolic aldehyde or aldose reductase. DOPAL is harmful to nigrostriatal DA terminals and contributes to the profound putamen DA deficiency found in Parkinson's disease. Cytosolic and mitochondrial aldehyde dehydrogenase (ALDH) isoenzymes deficiency in mice results in increased levels of DOPAL, causing neurodegeneration and motor dysfunction also associated with Parkinson's disease.
Molecular Weight:320.39
Molecular Formula:C21H20O3
Canonical SMILES:C1=CC=C(C=C1)COC2=C(C=C(C=C2)CO)OCC3=CC=CC=C3
InChI:InChI=1S/C21H20O3/c22-14-19-11-12-20(23-15-17-7-3-1-4-8-17)21(13-19)24-16-18-9-5-2-6-10-18/h1-13,22H,14-16H2
InChI Key:LADVXQNFPXBLDY-UHFFFAOYSA-N
References:Jinsmaa, Y., et al. Chem. Res. Toxicol., 22, 835 (2009); Goldstein, D. S., et al. J. Neurochem., 126, 591 (2013); Panneton, W. M., et al. PLoS One, 5, e15251 (2010); Wey, M. C., et al. PLoS One, 7, e31522 (2012).

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