3,4-Di(3-indolyl)-1H-pyrrole-2,5-dione - CAS 119139-23-0
Catalog: |
BB004414 |
Product Name: |
3,4-Di(3-indolyl)-1H-pyrrole-2,5-dione |
CAS: |
119139-23-0 |
Synonyms: |
3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione |
IUPAC Name: | 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione |
Description: | Bisindolylmaleimide IV (BIM IV) is an inhibitor of pyruvate phosphate dikinase (PPDK). It is a cell-permeable potent and somewhat selective inhibitor of PKC with IC50 of 87 nM. BIM IV is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 µM. It also inhibits protein kinase A (PKA) with an IC50 of 2.7 μM. |
Molecular Weight: | 327.34 |
Molecular Formula: | C20H13N3O2 |
Canonical SMILES: | C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54 |
InChI: | InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25) |
InChI Key: | DQYBRTASHMYDJG-UHFFFAOYSA-N |
Boiling Point: | 690.1 °C at 760 mmHg (Predicted) |
Melting Point: | 296.19 °C (Predicted) |
Flash Point: | 371.2±31.5 °C |
Purity: | > 98 % |
Density: | 1.486 g/cm3 |
Solubility: | Soluble in DMSO. |
Appearance: | Crystalline solid |
Storage: | Powder: -20°C 3 years 4°C 2 years In solvent: -80°C 6 months -20°C 1 months |
MDL: | MFCD00236432 |
LogP: | 3.54520 |
Vapor Pressure: | 0.0±2.2 mmHg at 25°C |
Publication Number | Title | Priority Date |
CN-111978298-A | Bis-indole maleimide fluorescence sensor containing aromatic amide group | 20200905 |
CN-111544432-A | Application of bisindolylmaleimide PKC inhibitor in preparation of medicine for treating myocarditis arrhythmia | 20200525 |
WO-2021173364-A1 | Treatment for chemobrain | 20200224 |
US-2021261587-A1 | STRAD-binding agents and Uses Thereof | 20200130 |
KR-20210079889-A | Microorganism including genetic modification that increases activity of multidrug efflux transport system, and method for preparing tryptophan metabolites using the same | 20191220 |
PMID | Publication Date | Title | Journal |
31396050 | 20190101 | PKC, AKT and ERK1/2-Mediated Modulations of PARP1, NF-κB and PEA15 Activities Distinctly Regulate Regional Specific Astroglial Responses Following Status Epilepticus | Frontiers in molecular neuroscience |
29669290 | 20180417 | Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice | Cell reports |
28189027 | 20170501 | The flame retardant 2,2',4,4'-Tetrabromodiphenyl ether enhances the expression of corticotropin-releasing hormone in the placental cell model JEG-3 | Chemosphere |
25866363 | 20150625 | Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells | Chemico-biological interactions |
24951586 | 20140808 | Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway | The Journal of biological chemistry |
Complexity: | 576 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 327.100776666 |
Formal Charge: | 0 |
Heavy Atom Count: | 25 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 3 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 327.100776666 |
Rotatable Bond Count: | 2 |
Topological Polar Surface Area: | 77.8 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 2.8 |
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