3,4,5-Tris(pivaloxy) 6-(tert-Butyldimethylsilyl)methyloxy Canagliflozin

Catalog: BB057663
Product Name: 3,4,5-Tris(pivaloxy) 6-(tert-Butyldimethylsilyl)methyloxy Canagliflozin
Synonyms: (2R,3R,4R,5S,6S)-2-(((tert-Butyldimethylsilyl)oxy)methyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)
Description:3,4,5-Tris(pivaloxy) 6-(tert-Butyldimethylsilyl)methyloxy Canagliflozin is an intermediate in the synthesis of Canagliflozin Dimer (C175225), a dimer impurity of Canagliflozin (C175190); a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
Molecular Weight:811.13
Molecular Formula:C45H63FO8SSi
References:Chao, E. et al. Drug Fut., 36, 351 (2011); Sha, S. et al. Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S. Clin. Invest., 1, 145 (2011).

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