3-[(4,5,6,7-Tetrahydro-2-indolyl)methylene]-2-indolinone - CAS 204003-85-0
Catalog: |
BB015894 |
Product Name: |
3-[(4,5,6,7-Tetrahydro-2-indolyl)methylene]-2-indolinone |
CAS: |
204003-85-0 |
Synonyms: |
(3Z)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indol-2-one; (3Z)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indol-2-one |
IUPAC Name: | (3Z)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indol-2-one |
Description: | 3-[(4,5,6,7-Tetrahydro-2-indolyl)methylene]-2-indolinone (CAS# 204003-85-0 ) is a useful research chemical. |
Molecular Weight: | 264.32 |
Molecular Formula: | C17H16N2O |
Canonical SMILES: | C1CCC2=C(C1)C=C(N2)C=C3C4=CC=CC=C4NC3=O |
InChI: | InChI=1S/C17H16N2O/c20-17-14(13-6-2-4-8-16(13)19-17)10-12-9-11-5-1-3-7-15(11)18-12/h2,4,6,8-10,18H,1,3,5,7H2,(H,19,20)/b14-10- |
InChI Key: | PEQAQVCHUDMZPB-UVTDQMKNSA-N |
Publication Number | Title | Priority Date |
EP-2872161-A2 | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof | 20120626 |
US-2015182490-A1 | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof | 20120626 |
WO-2014004376-A2 | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof | 20120626 |
EP-2872161-B1 | Dianhydrogalactitol for use in treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations | 20120626 |
EP-2134875-A2 | Biomarkers and methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators | 20070413 |
PMID | Publication Date | Title | Journal |
10893303 | 20000713 | Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases | Journal of medicinal chemistry |
Complexity: | 431 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 1 |
Exact Mass: | 264.126263138 |
Formal Charge: | 0 |
Heavy Atom Count: | 20 |
Hydrogen Bond Acceptor Count: | 1 |
Hydrogen Bond Donor Count: | 2 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 264.126263138 |
Rotatable Bond Count: | 1 |
Topological Polar Surface Area: | 44.9 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 2.9 |
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