Description: | (2R, 4S) - 2- (1, 1- Dimethylethyl) - 4- [(2E) - 1- hydroxy- 2- methyl- 2- butenyl] - 4- methyl-1, 3- oxathiolan- 5- one is a by-product intermediate in synthesizing (R)-(+)-Thiolactomycin (T350880). It is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO). |
Molecular Weight: | 240.36 |
Molecular Formula: | C13H20O2S |
Solubility: | Dichloromethane |
Appearance: | Yellow Oil |
References: | Kapilashrami, K., et al. J. Biol. Chem., 288, 6045 (2013); Paneerselvam, V., et al. J. Pharm. Res., 4, 4618 (2011); Katane, M., et al. Biochimie, 92, 1371 (2010). |
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