(2R)-3-(2-Chloro-4-nitro-1H-imidazol-1-yl)-2-methyl-1,2-propanediol - CAS 681490-91-5

Catalog: BB062336
Product Name: (2R)-3-(2-Chloro-4-nitro-1H-imidazol-1-yl)-2-methyl-1,2-propanediol
CAS: 681490-91-5
Synonyms: (R)-3-(2-Chloro-4-nitro-1H-imidazol-1-yl)-2-methylpropane-1,2-diol; (R)-2-chloro-1-(2,3-dihydroxy-2-methylpropyl)-4-nitroimidazole
(2R)-3-(2-Chloro-4-nitro-1H-imidazol-1-yl)-2-methyl-1,2-propanediol
IUPAC Name:(2R)-3-(2-chloro-4-nitroimidazol-1-yl)-2-methylpropane-1,2-diol
Description:(2R)-3-(2-Chloro-4-nitro-1H-imidazol-1-yl)-2-methyl-1,2-propanediol is an intermediate in the synthesis of Delamanid (D230660), a novel anti-tuberculosis medication that inhibits mycolic acid synthesis and shows potent in-vitro and in-vivo activity against drug-resistant strains of Mycobacterium tuberculosis.
Molecular Weight:235.62
Molecular Formula:C7H10ClN3O4
Canonical SMILES:CC(CN1C=C(N=C1Cl)[N+](=O)[O-])(CO)O
InChI:InChI=1S/C7H10ClN3O4/c1-7(13,4-12)3-10-2-5(11(14)15)9-6(10)8/h2,12-13H,3-4H2,1H3/t7-/m1/s1
InChI Key:UEYAJHCNNXRAIQ-SSDOTTSWSA-N
Solubility:Chloroform, DCM
Appearance:Off-White Solid
References:Sasaki, H., et al. J. Med. Chem., 49, 7854 (2006).

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