(2R)-1-(morpholin-4-yl)propan-2-ol - CAS 65617-06-3
Catalog: |
BB057857 |
Product Name: |
(2R)-1-(morpholin-4-yl)propan-2-ol |
CAS: |
65617-06-3 |
Synonyms: |
(R)-α-Methyl-4-morpholineethanol; (αR)-α-Methyl-4-morpholineethanol; (2R)-1-Morpholinopropan-2-ol; (R)-1-Morpholinopropan-2-ol; (R)-3-Morpholino-2-propanol |
IUPAC Name: | (2R)-1-morpholin-4-ylpropan-2-ol |
Description: | (2R)-1-(morpholin-4-yl)propan-2-ol (cas# 65617-06-3) is a useful research chemical. It is used in the preparation of quinazoline-based compounds as KRAS G12C inhibitor for treatment and/or alleviation of KRAS G12C-related diseases. |
Molecular Weight: | 145.19 |
Molecular Formula: | C7H15NO2 |
Canonical SMILES: | CC(CN1CCOCC1)O |
InChI: | InChI=1S/C7H15NO2/c1-7(9)6-8-2-4-10-5-3-8/h7,9H,2-6H2,1H3/t7-/m1/s1 |
InChI Key: | YAXQOLYGKLGQKA-SSDOTTSWSA-N |
References: | Guo, H., Faming Zhuanli Shenqing, 135pp. (2021). |
GHS Hazard Statement: | H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
CN-112574224-A | KRAS G12C inhibitor and application thereof | 20190930 |
WO-2021063346-A1 | Kras g12c inhibitor and application thereof | 20190930 |
US-2020331911-A1 | Kras g12c inhibitors | 20190110 |
WO-2020146613-A1 | Kras g12c inhibitors | 20190110 |
WO-2021141628-A1 | Kras g12c inhibitors | 20190110 |
EP-3908283-A1 | Kras g12c inhibitors | 20190110 |
JP-2022517222-A | KRAS G12C inhibitor | 20190110 |
WO-2020047192-A1 | Kras g12c inhibitors | 20180831 |
EP-3844151-A1 | Kras g12c inhibitors | 20180831 |
US-2021230170-A1 | Kras g12c inhibitors | 20180831 |
Complexity: | 91.6 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 1 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 145.110278721 |
Formal Charge: | 0 |
Heavy Atom Count: | 10 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 145.110278721 |
Rotatable Bond Count: | 2 |
Topological Polar Surface Area: | 32.7Ų |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | -0.4 |
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