(2R)-1-(morpholin-4-yl)propan-2-ol - CAS 65617-06-3

Name: (2R)-1-(morpholin-4-yl)propan-2-ol
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB057857
Product Name:	(2R)-1-(morpholin-4-yl)propan-2-ol
CAS:	65617-06-3
Synonyms:	(R)-α-Methyl-4-morpholineethanol; (αR)-α-Methyl-4-morpholineethanol; (2R)-1-Morpholinopropan-2-ol; (R)-1-Morpholinopropan-2-ol; (R)-3-Morpholino-2-propanol

Technical Data

IUPAC Name:	(2R)-1-morpholin-4-ylpropan-2-ol
Description:	(2R)-1-(morpholin-4-yl)propan-2-ol (cas# 65617-06-3) is a useful research chemical. It is used in the preparation of quinazoline-based compounds as KRAS G12C inhibitor for treatment and/or alleviation of KRAS G12C-related diseases.
Molecular Weight:	145.19
Molecular Formula:	C7H15NO2
Canonical SMILES:	CC(CN1CCOCC1)O
InChI:	InChI=1S/C7H15NO2/c1-7(9)6-8-2-4-10-5-3-8/h7,9H,2-6H2,1H3/t7-/m1/s1
InChI Key:	YAXQOLYGKLGQKA-SSDOTTSWSA-N
References:	Guo, H., Faming Zhuanli Shenqing, 135pp. (2021).

GHS Hazard Statement:	H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
Precautionary Statement:	P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501
Signal Word:	Danger

Publication Number	Title	Priority Date
CN-112574224-A	KRAS G12C inhibitor and application thereof	20190930
WO-2021063346-A1	Kras g12c inhibitor and application thereof	20190930
US-2020331911-A1	Kras g12c inhibitors	20190110
WO-2020146613-A1	Kras g12c inhibitors	20190110
WO-2021141628-A1	Kras g12c inhibitors	20190110
EP-3908283-A1	Kras g12c inhibitors	20190110
JP-2022517222-A	KRAS G12C inhibitor	20190110
WO-2020047192-A1	Kras g12c inhibitors	20180831
EP-3844151-A1	Kras g12c inhibitors	20180831
US-2021230170-A1	Kras g12c inhibitors	20180831

Complexity:	91.6
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	1
Defined Bond Stereocenter Count:	0
Exact Mass:	145.110278721
Formal Charge:	0
Heavy Atom Count:	10
Hydrogen Bond Acceptor Count:	3
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	145.110278721
Rotatable Bond Count:	2
Topological Polar Surface Area:	32.7Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	-0.4