Valpromide - CAS 2430-27-5

Name: Valpromide
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB018403
Product Name:	Valpromide
CAS:	2430-27-5
Synonyms:	Depamide; Dipropylacetamide

Technical Data

IUPAC Name:	2-propylpentanamide
Description:	Valpromide is an antiepileptic drug, derivative of Valproic acid, used as a mood-stabilizer in bipolar disorder. Valpromide is also used as an augmentation strategy in refractory depression.
Molecular Weight:	143.23
Molecular Formula:	C8H17NO
Canonical SMILES:	CCCC(CCC)C(=O)N
InChI:	InChI=1S/C8H17NO/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H2,9,10)
InChI Key:	OMOMUFTZPTXCHP-UHFFFAOYSA-N
Boiling Point:	274.6°C at 760 mmHg
Melting Point:	123-125°C
Flash Point:	119.9°C
Purity:	≥98% (HPLC)
Density:	0.885 g/cm3
Solubility:	Soluble in chloroform, dimethyl sulfoxide and methanol. Insoluble in water.
Appearance:	White crystalline powder
Storage:	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
MDL:	MFCD00051534
LogP:	2.38840
Vapor Pressure:	0.00535mmHg at 25°C

GHS Hazard Statement:	H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
Precautionary Statement:	P264, P270, P301+P312, P330, and P501
Signal Word:	Warning

Publication Number	Title	Priority Date
CN-113149823-A	2-R1Preparation method of valeric acid	20210329
WO-2021212039-A1	Inhibitors of cysteine proteases and methods of use thereof	20200417
US-10980756-B1	Methods of treatment	20200316
WO-2021185791-A1	Treatment of epilepsy	20200316
WO-2021188564-A1	Methods of treating covid-19 with a niclosamide compound	20200316

PMID	Publication Date	Title	Journal
23042728	20130101	Exposure to valproic acid inhibits chondrogenesis and osteogenesis in mid-organogenesis mouse limbs	Toxicological sciences : an official journal of the Society of Toxicology
22947425	20120901	Histone deacetylases are required for amphibian tail and limb regeneration but not development	Mechanisms of development
22003123	20120301	Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds	Disease models & mechanisms
22150444	20120101	A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage	Epilepsia
22363677	20120101	Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression	PloS one

Complexity:	95.4
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	143.131014166
Formal Charge:	0
Heavy Atom Count:	10
Hydrogen Bond Acceptor Count:	1
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	143.131014166
Rotatable Bond Count:	5
Topological Polar Surface Area:	43.1 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	2.1