Valpromide - CAS 2430-27-5
Catalog: |
BB018403 |
Product Name: |
Valpromide |
CAS: |
2430-27-5 |
Synonyms: |
Depamide; Dipropylacetamide |
IUPAC Name: | 2-propylpentanamide |
Description: | Valpromide is an antiepileptic drug, derivative of Valproic acid, used as a mood-stabilizer in bipolar disorder. Valpromide is also used as an augmentation strategy in refractory depression. |
Molecular Weight: | 143.23 |
Molecular Formula: | C8H17NO |
Canonical SMILES: | CCCC(CCC)C(=O)N |
InChI: | InChI=1S/C8H17NO/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H2,9,10) |
InChI Key: | OMOMUFTZPTXCHP-UHFFFAOYSA-N |
Boiling Point: | 274.6°C at 760 mmHg |
Melting Point: | 123-125°C |
Flash Point: | 119.9°C |
Purity: | ≥98% (HPLC) |
Density: | 0.885 g/cm3 |
Solubility: | Soluble in chloroform, dimethyl sulfoxide and methanol. Insoluble in water. |
Appearance: | White crystalline powder |
Storage: | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
MDL: | MFCD00051534 |
LogP: | 2.38840 |
Vapor Pressure: | 0.00535mmHg at 25°C |
GHS Hazard Statement: | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P264, P270, P301+P312, P330, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-113149823-A | 2-R1Preparation method of valeric acid | 20210329 |
WO-2021212039-A1 | Inhibitors of cysteine proteases and methods of use thereof | 20200417 |
US-10980756-B1 | Methods of treatment | 20200316 |
WO-2021185791-A1 | Treatment of epilepsy | 20200316 |
WO-2021188564-A1 | Methods of treating covid-19 with a niclosamide compound | 20200316 |
PMID | Publication Date | Title | Journal |
23042728 | 20130101 | Exposure to valproic acid inhibits chondrogenesis and osteogenesis in mid-organogenesis mouse limbs | Toxicological sciences : an official journal of the Society of Toxicology |
22947425 | 20120901 | Histone deacetylases are required for amphibian tail and limb regeneration but not development | Mechanisms of development |
22003123 | 20120301 | Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds | Disease models & mechanisms |
22150444 | 20120101 | A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage | Epilepsia |
22363677 | 20120101 | Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression | PloS one |
Complexity: | 95.4 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 143.131014166 |
Formal Charge: | 0 |
Heavy Atom Count: | 10 |
Hydrogen Bond Acceptor Count: | 1 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 143.131014166 |
Rotatable Bond Count: | 5 |
Topological Polar Surface Area: | 43.1 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 2.1 |
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